Atropine Weight and Risk of Postoperative Confusion After Hip Fracture Surgery or Prosthetic Surgery of the Lower Limb, in the Elderly
试验速览
- 阶段
- 不适用
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- Association between atropine load of medications on the risk of postoperative confusion
研究概览
简要总结
The identification of a high atropine load of treatment received during hospitalization as a predictor of postoperative confusion could have various benefits:
- Pharmacoepidemiological: identify factors associated with postoperative confusion
- Clinics: by favoring treatments with a low atropine load during anesthesia, the management of patients hospitalized in orthopedics. Similarly, stopping or re-evaluating treatments with a high atropine weight for scheduled surgery is an easy step to take.
- Socio-economic: by reducing the costs related to the occurrence of a confusional syndrome (over-treatment, prolonged hospital stay, loss of autonomy, institutionalization of patients...).
In total, the present study would improve the daily management of hospitalized patients and the practices of clinicians, by offering a decision-making aid.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Admitted to the orthopedic department for surgical management of a fracture of the upper end of the femur in emergency or for the installation of a hip or knee prosthesis
- •Patient able to understand and respond to the protocol
- •No opposition to the collection of data of the patient or his / her designee
排除标准
- •Pre-existing confusion to surgery, detected by the CAM scale
- •Serious or moderate head trauma less than three months old
- •Removing / installing prosthesis.
结局指标
主要结局
Association between atropine load of medications on the risk of postoperative confusion
时间窗: up to 7 days
Occurrence of a postoperative confusion syndrome performed by Confusion Assessment Method (CAM) scale once a day. The CAM is a validated scale as a diagnostic scale for confusional syndrome at the patient's bedside with four parts : 1) confusion and fluctuation of symptoms, 2) inattention, 3) disorganization of thought, 4) disorder of consciousness.
Atropinic load of drugs
时间窗: up to 7 days
The DURAN scale is the most recent and most comprehensive atropine load evaluation scale. This scale classifies the evaluated drugs into three categories: no anticholinergic power (atropine weight = 0), low anticholinergic activity (atropine weight = 1), high atropinic power (atropine weight = 3). All drugs received by the patient during 7 days will be classified with the Duran scale.
次要结局
- Duration of hospitalization(Up to discharge, an average of ten days)
- Autonomy(Month 3)
- Cognitive dysfunction(baseline)