Assessment of Use of Plasma or Serum IgG Test to Screen for Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,387
- 试验地点
- 12
- 主要终点
- Level of IgG antibodies in serum/plasma against periodontal pathogens
研究概览
简要总结
This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens.
详细描述
Background: Periodontitis is a prevalent silent infectious disease worldwide, and affects lifestyle-related diseases such as diabetes. Therefore, efficient screening of patients is essential for general health. This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens.
Methods: Oral examination was performed and blood IgG antibody titers against periodontal pathogens were measured by ELISA, in 1387 subjects. The cut-off value of IgG titer was determined in receiver operating characteristic curve analysis, and changes in periodontal clinical parameters and IgG titers by periodontal treatment were evaluated. The relationships between IgG titers and severity of periodontitis were analyzed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •periodontal patients
排除标准
- •difficulty of communication
- •received periodontal therapy within 3 months
- •with other diseases, i.e., hypertension, diabetes (self reported)
结局指标
主要结局
Level of IgG antibodies in serum/plasma against periodontal pathogens
时间窗: 1 to 3 months after basic periodontal treatment (Scaling and root planing)
Serum/plasma samples will be screened for the presence of IgG antibodies against the below mentioned periodontal pathogens, using the "ELISA" method. Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Prevotella intermedius, Porphyromonas gingivalis
次要结局
- Periodontal pocket depth(1 to 3 months after basic periodontal treatment)
- Bleeding on probing(1 to 3 monthsafter basic periodontal treatment)
- Tooth mobility(1 to 3 months after basic periodontal treatment)
研究者
Shogo Takashiba
Professor and Chair
Okayama University