Comparison of the Performance of an Optimized 3D EPI SWI Sequence and a Non-EPI QSM SWI Sequence in Detecting the Central Vein Sign in Patients With Multiple Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- percentage of lesions which do not present the sign of the central vein with the SWI EPI sequence but which present it with the candidate sequence
研究概览
简要总结
Patients who have agreed to participate in the study will complete the MRI protocol as part of routine care, to which four additional 20-minute sequences will be added.
MRI of routine care in the context of MS includes at least the following sequences:
- 3D T1 TFE (2 minutes)
- T2 TSE (2 minutes)
- 3D FLAIR (3 minutes)
- SWI EPI 0.6 iso (7 minutes)
The sequences added by the search are:
- SWI non EPI QSM 6 echo (10 minutes)
- SWI EPI in resolution equivalent to non-EPI SWI (3 minutes)
- SWI EPI to TR equivalent to SWI non EPI (6 minutes)
These sequences will be acquired before or after the injection of gadolinium (if present in the examination of routine care). For examinations carried out with injection, the order of carrying out the 4 post-injection SWI sequences will be random.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients over 18
- •With MS defined according to the McDonald's revised clinical or radiological spatial and temporal dissemination criteria, with onset of symptoms <5 years
- •To benefit as part of care from an MRI with or without injection of gadolinium
- •Express consent to participate in the study
- •Affiliate or beneficiary of a social security scheme
排除标准
- •Patient benefiting from a legal protection measure
- •Pregnant or breastfeeding woman
结局指标
主要结局
percentage of lesions which do not present the sign of the central vein with the SWI EPI sequence but which present it with the candidate sequence
时间窗: 1 day
percentage of lesions showing the central vein sign with the SWI EPI sequence that also show the central vein sign with the candidate sequence
时间窗: 1 day
次要结局
未报告次要终点