Content, Bioavailability and Health Effects of Trace Elements and Bioactive Components in Organic Agricultural Systems

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: Organic or conventional diet; Other: Diet (organic or conventional)

• Registration Number: NCT00738166
• Lead Sponsor: University of Copenhagen

Brief Summary

Trace elements, bioactive secondary metabolites and vitamins are among the most important quality parameters in plants. Yet, very little information is available on their content, bioavailability and health effects of organically grown plant food products. The main objective of the project is to study the impact of different agricultural management practises relevant for organic farming on the ability of cereal and vegetable crops to absorb trace elements from the soil and to synthesise bioactive compounds (secondary metabolites, antioxidant vitamins and phytates) with health promoting effects. Field experiments with a rigidly controlled design will be implemented together with state-of-the-art analytical techniques allowing solid conclusions to be drawn on the variability and optimum levels of bioactive compounds. The multitude of analytical data from plant and soil samples will be analysed by multivariate statistical methods in order to reveal differences between the cultivation systems used. Finally, the relationship between bioavailability of the nutrients studied and the elemental fingerprint of plants will be extracted by the statistical methods.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-10
• Study First Submitted: 2008-08-19
• Study First Submitted QC: 2008-08-19
• Study First Posted: 2008-08-20
• Primary Completion: 2010-01
• Study Completion: 2010-12
• Status Verified: 2011-02
• Last Update Submitted: 2016-07-27
• Last Update Posted: 2016-07-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• Healthy adults aged 18-45 years
• BMI 20-30 kg/m2
• Non-vegetarian

Exclusion Criteria

• Physical activity > 10 h/week
• Intake of dietary supplements
• Regular use of drugs
• Chronic diseases
• Smoking
• Excessive intake of alcohol

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
I	Diet (organic or conventional)	organic green manure
II	Organic or conventional diet	organic animal manure
III	Diet (organic or conventional)	conventional
II	Diet (organic or conventional)	organic animal manure
III	Organic or conventional diet	conventional
I	Organic or conventional diet	organic green manure

Primary Outcome Measures

Name	Time	Method
Bioavailability of trace elements and secondary metabolites	3 x 12 days

Secondary Outcome Measures

Name	Time	Method
Health factors	3 x 12 days

Trial Locations

Locations (1)

IHE-LIFE; 🇩🇰 Frederiksberg, Denmark