Formulation and Evaluation of Topical Preparation Containing Pomegranate and Ginkgo Biloba for Anti-aging Activities
试验速览
- 阶段
- 1 期
- 发起方
- 入组人数
- 30
- 试验地点
- 3
- 主要终点
- Measurement of ant-aging activity of Pomegranate and Ginkgo biloba
研究概览
简要总结
As the quality of life improves, people are seeking to look as young as they feel. Ginkgo biloba (GB) and Pomegranate (PG) extract can be used to create efficacious topical anti-aging products. GB & PG are now widely used in research and clinical trials on age-associated diseases, for example, skin aging, brain dysfunction, cardiovascular system diseases, carcinogen metabolism. The investigator's aim is to formulate a topical cream in the form (O/W or W/O emulsion) formulation, containing GB as an anti-aging formulation for the public.
详细描述
In this study, a vanishing cream will be prepared by reaction of a stearic acid with alkali (NaOH) to form stearate soap. Then the GB extract will be added to the final form. The formulated cream will be characterized for identifying the type of emulsion, calibration curve for GB, drug content, irritation to skin, homogeneity test, pH, FT-IR test, ex vivo studies, physical stability, and human application. Finally, a 9-questions questionnaire was published using Google forms for the human volunteers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of aging shape
- •Follow up and collect data for a local and systemic activity of Ginkgo Biloba and Pomegranate
- •The skin should be not injured as the cream can be easily applied
- •Systemic oral capsule Ginkgo Biloba and Pomegranate can be also given to enhance the activity as anti-aging activity
排除标准
- •Insulin-dependent diabetes
- •Hypertension disease
- •Skin wound
研究组 & 干预措施
Cream base
A group of volunteers receiving placebo medications without natural extracts of ginkgo biloba and Pomegranate.
干预措施: Cream Base (Drug)
Pomegrante and Ginkgo biloba group
A group of volunteers with the aging state receiving natural extracts of ginkgo biloba and Pomegranate in different topical dosage forms.
干预措施: Pomegrante and Ginkgo biloba group (Drug)
结局指标
主要结局
Measurement of ant-aging activity of Pomegranate and Ginkgo biloba
时间窗: Three months
The crow's feet wrinkle of 17 volunteers will be measured compared to the control group. The significant results will measure the decrease in the depths of deep furrows for groups treated with Pomegranate and Ginkgo biloba over a three months period.
次要结局
- Stable topical anti-aging products for long life shelf storage(Six months)
研究者
Ahmed A. H. Abdellatif
Assistant Prof. at Pharmaceutics dept., Faculty of Pharmacy, Qassim University, KSA
Al-Azhar University