Preventive and Personalized Medicine (2021-2023)
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 300
- Locations
- 1
- Primary Endpoint
- number of SNPs associated with bronchial asthma
Study Overview
Brief Summary
To research for a genetic marker of bronchial asthma, a single nucleotide polymorphism (SNP) analysis of DNA obtained from the peripheral blood of patients with bronchial asthma and normal control will be performed.
Detailed Description
Unrelated Kazaks subjects who have bronchial asthma were recruited in the current study. Genotyping for various SNP associated due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with bronchial asthma and normal control subjects free of bronchial asthma
Study Design
- Study Type
- Observational
- Observational Model
- Other
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 5 Years to 65 Years (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Persons with bronchial asthma confirmed by a doctor;
- •The age of the patients is from 5 to 60 years;
- •Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs.
- •Persons who are able and willing to provide written informed consent;
- •Persons capable and willing to comply with the research protocol;
Exclusion Criteria
- •Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
- •Pregnant or lactating women;
- •Tuberculosis of any localization in the active phase and in history;
- •Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
- •Severe and decompensated course of endocrine diseases;
- •Autoimmune diseases;
- •Systemic diseases;
- •Oncological diseases;
Outcomes
Primary Outcomes
number of SNPs associated with bronchial asthma
Time Frame: 1 year
Using SNPsto identify candidate genes associate with bronchial asthma
Secondary Outcomes
No secondary outcomes reported
Investigators
Ildar Fakhradiyev
Project manager
Asfendiyarov Kazakh National Medical University