The Role of Genetic Factors in the Development of Bronchial Asthma in the Kazakh Population

Completed

• Conditions: Bronchial Asthma; Genome Wide Association Studies
• Interventions: Genetic: SNP analysis of the DNA

• Registration Number: NCT05088512
• Lead Sponsor: Asfendiyarov Kazakh National Medical University

Brief Summary

To research for a genetic marker of bronchial asthma, a single nucleotide polymorphism (SNP) analysis of DNA obtained from the peripheral blood of patients with bronchial asthma and normal control will be performed.

Detailed Description

Unrelated Kazaks subjects who have bronchial asthma were recruited in the current study. Genotyping for various SNP associated due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with bronchial asthma and normal control subjects free of bronchial asthma

Study Timeline

• Study First Submitted: 2021-09-25
• Study First Submitted QC: 2021-10-21
• Study First Posted: 2021-10-22
• Study Start: 2021-10-23
• Primary Completion: 2023-01-20
• Study Completion: 2023-01-20
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-13
• Last Update Posted: 2023-03-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Persons with bronchial asthma confirmed by a doctor;
• The age of the patients is from 5 to 60 years;
• Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs.
• Persons who are able and willing to provide written informed consent;
• Persons capable and willing to comply with the research protocol;

Exclusion Criteria

• Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
• Pregnant or lactating women;
• Tuberculosis of any localization in the active phase and in history;
• Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
• Severe and decompensated course of endocrine diseases;
• Autoimmune diseases;
• Systemic diseases;
• Oncological diseases;

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Experimental group:	SNP analysis of the DNA	Patients with bronchial asthma
Control group	SNP analysis of the DNA	Patients without bronchial asthma

Primary Outcome Measures

Name	Time	Method
number of SNPs associated with bronchial asthma	1 year	Using SNPsto identify candidate genes associate with bronchial asthma

Trial Locations

Locations (1)

Kazakhstan; 🇰🇿 Almaty, Kazakhstan