A Phase 2, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of Trastuzumab Deruxtecan (T-DXd, DS-8201a) for the Treatment of Selected HER2 Expressing Tumors (DESTINY-PanTumor02)

AstraZeneca90 个研究点分布在 12 个国家目标入组 477 人开始时间: 2020年8月18日最近更新: 2026年7月10日

适应症

干预措施

试验速览

阶段: 2 期
状态: 进行中（未招募）
发起方: AstraZeneca
入组人数: 477
试验地点: 90
主要终点: Objective Response Rate (ORR)

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验相关资讯

研究概览

简要总结

This is an open-label, multi-center, multi-cohort, Phase 2 study to evaluate the efficacy and safety of trastuzumab deruxtecan (T-DXd) for the treatment of selected HER2-expressing tumors.

This study will consist of Part 1 which includes 7 cohorts of: urothelial bladder cancer, biliary tract cancer, cervical cancer, endometrial cancer, ovarian cancer, pancreatic cancer, and rare tumors; and Part 2 which includes 5 cohorts A to E of: A) any tumor type that is HER2 IHC 3+ (excluding breast, gastric cancer, and colorectal cancer), B) any tumor type that is HER2 IHC 2+/ISH+ (excluding breast, gastric cancer, and colorectal cancer), C) HER2 IHC 2+ or 1+ endometrial cancer, D) HER2 IHC 2+ or 1+ ovarian cancer, and E) HER2 IHC 2+ or 1+ cervical cancer.

Study hypothesis: Trastuzumab deruxtecan will show meaningful clinical activity and a favorable risk benefit profile in selected HER2-expressing solid tumors.

研究设计

研究类型: Interventional
分配方式: Non Randomized
干预模型: Parallel
主要目的: Treatment
盲法: None

盲法说明

This study is Open-Label Study.

入排标准

年龄范围: 18 Years 至 120 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Locally advanced, unresectable, or metastatic disease based on most recent imaging.
•Part 1:The respective cohorts for patient inclusion are:
•Cohort 1: Biliary tract cancer
•Cohort 2: Bladder cancer
•Cohort 3: Cervical cancer
•Cohort 4: Endometrial cancer
•Cohort 5: Epithelial ovarian cancer
•Cohort 6: Pancreatic cancer
•Cohort 7: Rare tumors: This cohort will consist of patients with tumors that express HER2, excluding the tumors mentioned above, and breast, non-small cell lung cancer, gastric cancer, and colorectal cancer.
•Part 2:The respective cohorts for patient inclusion are:
•Cohort A: Metastatic or advanced solid tumors that are HER2 IHC 3+ (excluding breast, gastric cancer, and colorectal cancer). Patients with non-small cell lung cancer can be included.
•Cohort B: Metastatic or advanced solid tumors that are HER2 IHC 2+/ISH+ any tumor type (excluding breast, gastric cancer, and colorectal cancer). Patients with non-small cell lung cancer can be included.
•Cohort C: Metastatic or advanced solid endometrial cancer that is HER2 IHC 2+ or 1+.
•Cohort D: Metastatic or advanced ovarian cancer that is HER2 IHC 2+ or 1+.
•Cohort E: Metastatic or advanced solid cervical cancer that is HER2 IHC 2+ or 1+.
•Progressed following prior treatment or who have no satisfactory alternative treatment option.
•Prior HER2 targeting therapy is permitted.
•HER2 expression scored using current ASCO/CAP guidelines for scoring HER2 for gastric cancer.
•Part 1: IHC 3+ or IHC 2+ by local or central assessment
•Part 2: IHC and ISH results by central assessment as pre-defined for each cohort
•Has measurable target disease assessed by the Investigator based on RECIST version 1.
•Has protocol- defined adequate organ function including cardiac, renal and hepatic function.

排除标准

•History of non-infectious pneumonitis/ILD that required steroids, current ILD, or where suspected ILD that cannot be ruled out by imaging at screening
•Lung-specific intercurrent clinically significant severe illnesses
•Uncontrolled infection requiring intravenous (IV) antibiotics, antivirals, or antifungals
•Pleural effusion, ascites or pericardial effusion that requires drainage, peritoneal shunt, or Cell-free and Concentrated Ascites Reinfusion Therapy (CART
•Known Somatic DNA mutation of HER2 (ERBB2) without tumoral HER2 protein expression.
•Primary diagnosis of adenocarcinoma of the breast, adenocarcinoma of the colon or rectum, adenocarcinoma of the gastric body or gastro-esophageal junction, or non-small cell lung cancer for Part
•For Part 2, patients with primary diagnosis of adenocarcinoma of the breast, adenocarcinoma of the colon or rectum, adenocarcinoma of the gastric body or gastro-esophageal junction will be excluded.
•Medical conditions that may interfere with the subject's participation in the study.