CTIS2023-506432-32-00招募中1 期
Comparison of treatment completion rates with three short-course rifamycin-based regimens (three months of daily isoniazid plus rifampicin [3HR], three months of once-weekly isoniazid plus rifapentine [3HP], and four months of daily rifampicin [4R]) for treatment of latent tuberculosis infection in patients with end-stage kidney disease: A randomised controlled clinical trial (RIFAKiD-TB Trial) - PI21/004444
适应症
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 入组人数
- 225
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 65+（—）
- 性别
- All
入选标准
- •1. Patients 18 years or older with kidney disease stage 5 (glomerular filtrate rate <15 mL/minute or under substitutive renal therapy) who require treatment for latent tuberculosis infection., 2. Female with negative pregnancy test prior to enrolment., 3. Female of childbearing age willing to take appropriate barrier contraceptive measures., 4. Informed written consent.
排除标准
- •1. Prior allergy/intolerance to rifamycins or isoniazid., 2. Pregnancy or breastfeeding., 3. Pre-treatment transaminases (ALT and/or AST) >5-fold of the upper limit of the normality titer., 4. Concomitant treatment with drugs contraindicated with the study medications., 5. Having received rifamycins or isoniazid within the two previous weeks., 6. Weigh <32 Kgs., 7. Inability to understand the nature of the study or to give written consent.
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