A decision model for the management of acute exacerbation chronic obstructive pulmonary disease in the emergency department: flowchart for treatment allocation.

Completed

• Conditions: 10038716; Acute Exacerbation Chronic Obstructive Pulmonary Disease / AECOPD

• Registration Number: NL-OMON44069
• Lead Sponsor: HagaZiekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 300

Inclusion Criteria

- Patient is previously diagnosed with COPD supported by spirometric evidence of airflow obstruction FEV1/VC < LLN), age > 35 years, smoking history (>1 Pack Year). Or diagnosed within three months after inclusion in stable pulmonary situation.
- Patient is presenting with a probable or certain exacerbation of COPD, defined as: An acute event characterized by a worsening of the patient*s respiratory symptoms that is beyond day-to-day variations and leads to a change in medication.

Exclusion Criteria

- Active malignancy with life expectancy < 12 months
- Dyspnoea otherwise explained: e.g. pulmonary embolism, acute cardiac event, pneumothorax, etc.
- New consolidation on chest radiograph suggestive for pneumonia
- Comorbidity requiring hospitalization independent of severity of AECOPD: e.g. acute renal insufficiency, electrolyte disorder, decompensated heart failure, etc.
- The subject is incapacitated

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoint is admission rate.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary study endpoints are readmission rate, average length of stay when<br /><br>admitted, healthcare costs, 30-day mortality rate and health status.</p><br>