IRCT20180929041167N1招募中2 期
Randomized clinical trial of the comparison of the effectiveness of topiramate in reducing craving in patients with methamphetamine use disorder
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 56
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 65 years（—）
- 性别
- All
入选标准
- •Age between 18 to 65 years
- •Current diagnosis of methamphetamine use disorder based on DSM-V criteria
- •Positive urine test for methamphetamine prior to study entry or self report of methamphetamine use for at least 5 days during the previous month
- •Body mass index equal or greater than 18
排除标准
- •Comorbid medical conditions based on medical history, physical examination, and laboratory test results
- •Use of other substances (except for methadone as a maintenance therapy, nicotine, and cannabis) confirmed by toxicology screening
- •Use of medications known to interact with topiramate such as acetazolamide, ergotamines, simvastatin, lovastatin, and antiepileptics
- •History of hypersensetivity to topiramate
- •Impaired renal function
- •History of kidney stone
- •Serious mood disorders (i.e. major depressive disorder, bipolar disorder), suicidal ideation, schizophrenia, psychosis (exept for transient psychosis due to substance use), dementia, psychiatric disorders requiring psychotropic medications (exept for medication for insomnia)
- •Use of medications with potential effect on methamphetamine craving (i.e. modafinil, bupropion, naltrexone, N-acetylcycteine)
- •Pregnancy and or lactation
- •Currently (during a month prior to the study) in treatment for methamphetamine use
- •Having DSM-V diagnosis of any other substance use disorders in the previous year
- •Coronary vascular disease confirmed by physical examination and electrocardiography
- •History of seizure
- •History of glucoma
- •Having DSM-V axis I psychiatric disorders that will probabely need treatment during the study duration or that are unstable
- •Patients referred by court seeking treatment for penatly rebate
研究者
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