IRCT20180929041167N1
Recruiting
Phase 2
Randomized clinical trial of the comparison of the effectiveness of topiramate in reducing craving in patients with methamphetamine use disorder
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Iran University of Medical Sciences
- Enrollment
- 56
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age between 18 to 65 years
- •Current diagnosis of methamphetamine use disorder based on DSM\-V criteria
- •Positive urine test for methamphetamine prior to study entry or self report of methamphetamine use for at least 5 days during the previous month
- •Body mass index equal or greater than 18
Exclusion Criteria
- •Comorbid medical conditions based on medical history, physical examination, and laboratory test results
- •Use of other substances (except for methadone as a maintenance therapy, nicotine, and cannabis) confirmed by toxicology screening
- •Use of medications known to interact with topiramate such as acetazolamide, ergotamines, simvastatin, lovastatin, and antiepileptics
- •History of hypersensetivity to topiramate
- •Impaired renal function
- •History of kidney stone
- •Serious mood disorders (i.e. major depressive disorder, bipolar disorder), suicidal ideation, schizophrenia, psychosis (exept for transient psychosis due to substance use), dementia, psychiatric disorders requiring psychotropic medications (exept for medication for insomnia)
- •Use of medications with potential effect on methamphetamine craving (i.e. modafinil, bupropion, naltrexone, N\-acetylcycteine)
- •Pregnancy and or lactation
- •Currently (during a month prior to the study) in treatment for methamphetamine use
Outcomes
Primary Outcomes
Not specified
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