Comparison of Analgesic Consumption Between Perioperative ıv Dexamethasone and Added to Femoral Block

Phase 4

• Conditions: Postoperative Pain
• Interventions: Drug: iv dexamethasone; Drug: serum physiologic; Drug: femoral dexamethasone

• Registration Number: NCT02090790
• Lead Sponsor: TC Erciyes University

Brief Summary

the aim of this study was to investigate compare the effect of peroperative intravenous single dose dexamethasone and the addition of dexamethasone to femoral nerve block on postoperative analgesic consumption and patient comfort in unilateral total knee arthroplasty patients

Detailed Description

Total knee arthroplasty leads to severe postoperative pain. for postoperative pain control after total knee arthroplasty oral -intramuscular opioids ,patient controlled analgesia intravenous or epidural opioids, single -continuous femoral nerve block involving techniques are used.

Dexamethasone is a glucocorticoid of high potency and frequently used perioperative.Dexamethasone to the local anaesthetic solution administered trough in femoral nerve blocks significantly prolonged the analgesic effect of the local anaesthetics used on this blocks.If the analgesic efficacy of systemic treatment with dexamethasone is similar with the use of perineural wich is the safest way should be preferred for systemic use.

Study Timeline

• Status Verified: 2014-03
• Study Start: 2014-03
• Study First Submitted: 2014-03-17
• Study First Submitted QC: 2014-03-17
• Study First Posted: 2014-03-18
• Last Update Submitted: 2014-03-20
• Last Update Posted: 2014-03-21
• Primary Completion: 2014-06
• Study Completion: 2014-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• between 18-65 age
• knee arthroplasty
• no known allergies to drugs
• ASA 1-2 patients

Exclusion Criteria

• history of diabetes
• history of chronic pain treatment
• pregnancy
• severe bronchopulmonary disease
• systemic opioid and steroid use

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
iv dexamethasone	iv dexamethasone	perioperative 2ml 8 mg ıv dexamethasone
serum physiologic	serum physiologic	-
femoral dexamethasone	femoral dexamethasone	femoral block was performed postoperative 30 ml 0,5 % bupivacaine added 2 ml 8 mg dexamethasone

Primary Outcome Measures

Name	Time	Method
visual analog scale	postoperative 2 day

Secondary Outcome Measures

Name	Time	Method
analgesic consumption	postoperative 2 day	morphine consumption (patient controlled analgesia procedure)

Trial Locations

Locations (1)

Erciyes Univercity Hospital; 🇹🇷 Kayseri, Turkey