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临床试验/NCT02090790
NCT02090790Unknown4 期

The Compare the Effect of Peroperative Intravenous Single Dose Dexamethasone and the Addition of Dexamethasone to Femoral Nerve Block on Postoperative Analgesic Consumption Anf Patient Comfort in Unilateral Total Knee Arthroplasty Patients

TC Erciyes University1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2014年3月最近更新:
适应症
干预措施
相关药物

试验速览

阶段
4 期
入组人数
60
试验地点
1
主要终点
visual analog scale

研究概览

简要总结

the aim of this study was to investigate compare the effect of peroperative intravenous single dose dexamethasone and the addition of dexamethasone to femoral nerve block on postoperative analgesic consumption and patient comfort in unilateral total knee arthroplasty patients

详细描述

Total knee arthroplasty leads to severe postoperative pain. for postoperative pain control after total knee arthroplasty oral -intramuscular opioids ,patient controlled analgesia intravenous or epidural opioids, single -continuous femoral nerve block involving techniques are used.

Dexamethasone is a glucocorticoid of high potency and frequently used perioperative.Dexamethasone to the local anaesthetic solution administered trough in femoral nerve blocks significantly prolonged the analgesic effect of the local anaesthetics used on this blocks.If the analgesic efficacy of systemic treatment with dexamethasone is similar with the use of perineural wich is the safest way should be preferred for systemic use.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • between 18-65 age
  • knee arthroplasty
  • no known allergies to drugs
  • ASA 1-2 patients

排除标准

  • history of diabetes
  • history of chronic pain treatment
  • pregnancy
  • severe bronchopulmonary disease
  • systemic opioid and steroid use

研究组 & 干预措施

iv dexamethasone

Active Comparator

perioperative 2ml 8 mg ıv dexamethasone

干预措施: iv dexamethasone (Drug)

femoral dexamethasone

Active Comparator

femoral block was performed postoperative 30 ml 0,5 % bupivacaine added 2 ml 8 mg dexamethasone

干预措施: femoral dexamethasone (Drug)

serum physiologic

Placebo Comparator

干预措施: serum physiologic (Drug)

结局指标

主要结局

visual analog scale

时间窗: postoperative 2 day

次要结局

  • analgesic consumption(postoperative 2 day)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

ahmet öner

resident

TC Erciyes University

研究点 (1)

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