Decreased salivary flow rate as a dipsogenic factor in haemodialysis patients: a pilocarpine clinical trial

ational Cheng Kung University (Taiwan)0 个研究点目标入组 60 人开始时间: 2005年4月19日最近更新: 2015年1月13日

试验速览

暂无简介。

•In the observational study, we collected prospective data for 3 consecutive months (December 2002 to February 2003) from 90 participants recruited from a pool of 217 patients undergoing HD at the outpatient dialysis unit of the Kuo's General Hospital. Inclusion criteria included:
•1. Maintenance HD three times weekly for at least 6 months
•2. Over 18 years of age
•3. Daily urine output less than 200 ml
•4. Stable clinical condition with stable dry weight and hematocrit
•The inclusion and exclusion criteria for the intervention study (March to October 2003), were the same as those for the observation study except that:
•5. Only hyperdipsic patients (IDWG % greater than 2%/day) were included
•6. Patients using the xerogenic mediations were included if these drugs could be stopped at least 14 days before entering and throughout the interventional study

•1. Haemodynamic instability preventing sufficient ultrafiltration
•2. Hospitalisation within the preceding 3 months
•3. Dementia or terminal diseases
•4. Those not feasible to investigate for logistic reasons
•5. Depression or anxiety (which cause xerostomia possibly due to the dysfunction of both brain and salivary glands)
•6. Using xerogenic mediations (including anticholinergies, antidepressants, antipsychotics, antihistamines, antiparkinsonian agents, and diuretics)
•7. Unwilling to participate in this study

发起方

ational Cheng Kung University (Taiwan)