Biomarkers of Atrial Fibrillation Complicated With Stroke Based on Proteomics and Metabolomics
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Biomarkers of atrial fibrillation complicated with stroke based on proteomics and metabolomics
研究概览
简要总结
Thrombus shedding in patients with atrial fibrillation (AF) can lead to cerebral artery embolism. Stroke caused by AF is very dangerous, which not only threatens the life of patients, but also seriously affects the quality of life. This study aims to explore the biomarkers of stroke in patients with AF by integrating proteomics and metabolomics data, and establish the network relationship of stroke in patients with AF, so as to reveal the molecular mechanism of stroke in patients with AF.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 years or above
- •Admission with atrial fibrillation or clinic visit for atrial fibrillation
- •Receive routine anticoagulant therapy;
- •Signing the consent form
排除标准
- •Pregnant women;
- •Lactating women;
- •Severe mitral stenosis;
- •Severe impairment of liver function;
- •Severe renal insufficiency;
- •Thyroid dysfunction requiring treatment.
结局指标
主要结局
Biomarkers of atrial fibrillation complicated with stroke based on proteomics and metabolomics
时间窗: 1 day
By combining proteomics and metabolomics data, the investigators were able to identify the common pathways involved in AF with stroke.
次要结局
- Quantitative changes of individual metabolites and proteins were calculated and graphed using the KEGG mapping tools.(1 day)
- By combining proteomics and metabolomics data, the investigators were able to identify the common pathways involved in AF with stroke.(1 day)
- All of the omics data were used to compare proteins/enzymes with metabolic pathways.(1 day)
研究者
Yue LI
Professor
First Affiliated Hospital of Harbin Medical University