Biomarkers of Atrial Fibrillation Complicated With Stroke Based on Proteomics and Metabolomics
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Atrial Fibrillation
- Sponsor
- Yue LI
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Biomarkers of atrial fibrillation complicated with stroke based on proteomics and metabolomics
- Last Updated
- 4 years ago
Overview
Brief Summary
Thrombus shedding in patients with atrial fibrillation (AF) can lead to cerebral artery embolism. Stroke caused by AF is very dangerous, which not only threatens the life of patients, but also seriously affects the quality of life. This study aims to explore the biomarkers of stroke in patients with AF by integrating proteomics and metabolomics data, and establish the network relationship of stroke in patients with AF, so as to reveal the molecular mechanism of stroke in patients with AF.
Investigators
Yue LI
Professor
First Affiliated Hospital of Harbin Medical University
Eligibility Criteria
Inclusion Criteria
- •Age 18 years or above
- •Admission with atrial fibrillation or clinic visit for atrial fibrillation
- •Receive routine anticoagulant therapy;
- •Signing the consent form
Exclusion Criteria
- •Pregnant women;
- •Lactating women;
- •Severe mitral stenosis;
- •Severe impairment of liver function;
- •Severe renal insufficiency;
- •Thyroid dysfunction requiring treatment.
Outcomes
Primary Outcomes
Biomarkers of atrial fibrillation complicated with stroke based on proteomics and metabolomics
Time Frame: 1 day
By combining proteomics and metabolomics data, the investigators were able to identify the common pathways involved in AF with stroke.
Secondary Outcomes
- Quantitative changes of individual metabolites and proteins were calculated and graphed using the KEGG mapping tools.(1 day)
- By combining proteomics and metabolomics data, the investigators were able to identify the common pathways involved in AF with stroke.(1 day)
- All of the omics data were used to compare proteins/enzymes with metabolic pathways.(1 day)