Analysis of Risk Factors for Antibiotic-Resistance Staphylococcus aureus Infection in Community.

Not Applicable

Completed

Conditions: Certain infectious and parasitic diseases

Registration Number: KCT0001088

Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary: 1) A total of 240 cases of community-acquired Staphylococcus aureus bacteremia were registered in this cohort, and community acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) was 20.8% (50 cases). 2) Because the number of cases is less than the target number, we collected more data from previous cohort studies to have sufficient statistical power for risk factor analysis.The enrolled cohorts were the cohort from June 2009 to June 2011 and the cohort from May to December 2012. All of these cohort studies were perfomed using a similar study design. 3) Using these cohorts, this study analyzed the risk factors for methicillin-resistant of Staphylococcus aureus in community. 4) We analyzed community-onset methicillin resistant Staphylococcus aureus bacteremia for clinical application and a total of 1802 cases were included. 5) The risk factors for methicillin-resistance were analyzed.The most powerful predictors of methicillin-resistance were previous isolation of MRSA within 6 months and history of hospitalization or surgery. The negative correlation factors were underlying hematologic disease and endovascular infetion as the primary site of infection. 6) Using these risk factors and negative correlation factors, the scoring system for predicting methicillin-resistance was established in community-onset Sthaphylococcus aureus. With this scoring system, cases were classified into low, intermediate, and high risk groups. 7) The proportion of MRSA in each group was 24.7% (22/89), 39.0% (607/1557) and 78.8% (123/156)

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 250

Inclusion Criteria

Among all adult (>=18years) patients with Staphylococcus aureus bacteremia at participating hospital during the study period
1) Patients who agree to the gathering clinical information about S. aureus bacteremia by means of an informed consent.
2) Patients who fulfill the criteria of a waiver: Patients who died or transferred within 2 weeks after the onset of bacteremia, an informed consent was waived by institutional review board.

Exclusion Criteria

Patienst who do not agree the participation in this study, except for patients who fulfill the criteria of a waiver of informed consent.