Temporal Relations and Exercise Interventions of Various Gait and Cognitive Domains in Older Adults
- Conditions
- FallersMild Cognitive Impairment
- Interventions
- Behavioral: Exercise
- Registration Number
- NCT03839563
- Lead Sponsor
- Taipei Medical University
- Brief Summary
The effectiveness of conventional exercise, tai chi chuan and health education/usual physical activity over a 6-month intervention period in improving primary outcomes and secondary outcomes in older mild cognitive impairment adults will be compared. Third, whether changes in serum levels of the brain-derived neurotrophic factor (BDNF), insulin-like growth factor (IGF)-1, and vascular endothelial growth factor (VEGF) and expression of the apolipoprotein E (APOE) ε4 allele parallel changes in gait characteristics and cognitive functions after the intervention will be examined.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 189
- At least 65 years old
- Had an emergency department visit due to a fall at least 3 months prior to the baseline assessment (assuming a full recovery time from a fall to be 3 months)
- Can ambulate independently
- Has mild cognitive impairment
- Do not live in a community setting
- Cannot ambulate independently and communicate with researchers
- Have a major unstable cardiopulmonary disease (e.g., ischemic chest pain, shortness of breath, recurrent syncopal episodes, orthopnea, paroxysmal nocturnal dyspnea, palpitations, or tachycardia)
- Have a contraindication to physical exercise (e.g., severe osteoarthritis or severe pulmonary hypertension)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Tai chi chuan Exercise The 8-form Yang-style tai chi chuan intervention will take place at a subject's residence or in the neighborhood once a week for 6 months, and each session will last 60 min. Conventional exercise Exercise This exercise will comprise stretching, muscle strengthening, and balance training at increasing difficulty levels, tailored and supervised by a physical therapist, and will take place at a subject's residence or in the neighborhood once a week for 6 months. Each session will last 60 min.
- Primary Outcome Measures
Name Time Method Serum levels of IGF-1 12 months Serum IGF-1 concentrations will be assessed.
Serum levels of BDNF 12 months Serum BDNF concentrations will be assessed.
Serum levels of VEGF 12 months Serum VEGF concentrations will be assessed.
Gait characteristics 12 months Performance on six gait characteristics (velocity, cadence, stride length, swing time, stride length variability, and swing time variability) will be measured with a 6-m electronic walkway of GAITRite.
Global cognition 12 months Global cognition will be assessed using the Mini-Mental State Examination (MMSE). The MMSE comprises 11 questions, and the score ranges 0\~30, with lower scores indicating poorer global cognition.
- Secondary Outcome Measures
Name Time Method Falls 12 months number of falls and multiple falls
Fear of falling 12 months Fear of falling will be assessed using the Falls Efficacy Scale (FES) test.
Mobility 12 months The timed up and go test requires subjects to rise from a standard chair, walk a distance of 3 m, turn, walk back to the chair, and sit down. The time to complete the timed up and go will be recorded.
Muscle strength 12 months Grip strength will be assessed via a handgrip dynamometer and measured in kilograms of isometric force.
Tinetti balance 12 months The Tinetti balance score ranges 0\~26, with a higher score indicating a better balance ability.
Depressive symptoms 12 months Depressive symptoms will be assessed using the 15-item Geriatric Depression Scale (GDS).
Trial Locations
- Locations (1)
Taipei Medical University
🇨🇳Taipei, Taiwan