Temporal Relations and Exercise Interventions of Various Gait and Cognitive Domains in Older Adults
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Taipei Medical University
- Enrollment
- 189
- Locations
- 2
- Primary Endpoint
- Serum levels of IGF-1
Study Overview
Brief Summary
The effectiveness of conventional exercise, tai chi chuan and health education/usual physical activity over a 6-month intervention period in improving primary outcomes and secondary outcomes in older mild cognitive impairment adults will be compared. Third, whether changes in serum levels of the brain-derived neurotrophic factor (BDNF), insulin-like growth factor (IGF)-1, and vascular endothelial growth factor (VEGF) and expression of the apolipoprotein E (APOE) ε4 allele parallel changes in gait characteristics and cognitive functions after the intervention will be examined.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 65 Years to 100 Years (Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •At least 65 years old
- •Had an emergency department visit due to a fall at least 3 months prior to the baseline assessment (assuming a full recovery time from a fall to be 3 months)
- •Can ambulate independently
- •Has mild cognitive impairment
Exclusion Criteria
- •Do not live in a community setting
- •Cannot ambulate independently and communicate with researchers
- •Have a major unstable cardiopulmonary disease (e.g., ischemic chest pain, shortness of breath, recurrent syncopal episodes, orthopnea, paroxysmal nocturnal dyspnea, palpitations, or tachycardia)
- •Have a contraindication to physical exercise (e.g., severe osteoarthritis or severe pulmonary hypertension)
Outcomes
Primary Outcomes
Serum levels of IGF-1
Time Frame: 12 months
Serum IGF-1 concentrations will be assessed.
Serum levels of BDNF
Time Frame: 12 months
Serum BDNF concentrations will be assessed.
Serum levels of VEGF
Time Frame: 12 months
Serum VEGF concentrations will be assessed.
Gait characteristics
Time Frame: 12 months
Performance on six gait characteristics (velocity, cadence, stride length, swing time, stride length variability, and swing time variability) will be measured with a 6-m electronic walkway of GAITRite.
Global cognition
Time Frame: 12 months
Global cognition will be assessed using the Mini-Mental State Examination (MMSE). The MMSE comprises 11 questions, and the score ranges 0\~30, with lower scores indicating poorer global cognition.
Secondary Outcomes
- Falls(12 months)
- Mobility(12 months)
- Fear of falling(12 months)
- Muscle strength(12 months)
- Tinetti balance(12 months)
- Depressive symptoms(12 months)