ISRCTN16793907已完成未知
The effects of Cosmos caudatus (ulam raja) extract in improving cognitive function, brain activity, mood state and health parameters among older adults with mild cognitive impairment
niversiti Kebangsaan Malaysia [National University of Malaysia]0 个研究点目标入组 48 人开始时间: 2019年12月20日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 48
研究概览
简要总结
2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33572715/ (added 17/01/2023)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Malaysian older adults aged 60-75 years at the time of informed consent
- •2. Mild cognitive impairment based on Petersen’s criteria:
- •2.1. No clinical judgment of dementia
- •2.2. No or very minimal limitations in Instrumental Activities of Daily Living (IADL) with a score of =1.5 SD from mean norm
- •2.3. Essentially preserved general cognitive functioning, with a score =19 in Mini Mental State Examination (MMSE)
- •2.4. Objective memory impairment, with a score of at least 1.5 SD below the mean average in one or more cognitive tests (Rey Auditory Verbal Learning Test [RAVLT] or Digit Span)
- •3. Able to communicate in Malay or English language
- •4. Body mass index (BMI) of 20-30 kg/m2
排除标准
- •1. Alcohol and/or substance dependence
- •3. Any type of neurodegenerative diseases (i.e. Parkinson disease, dementia, etc)
- •4. Diagnosis of a depressive disorder, schizophrenia or score >5 in Geriatric Depression Scale (GDS)
- •5. Any medical conditions that might interfere with the subject’s participation in the trial (i.e. uncontrolled diabetes, chronic heart disease, cancer and kidney, liver or renal failure)
- •6. Attention Deficit Hyperactivity Disorder (ADHD) or other conditions that might interfere with the outcomes, such as cognition function and psychosocial status
- •7. Regular consumer of traditional herbs, vitamin and mineral supplementation for the past 6 months, since this might jeopardize the effects of the supplement used in the study
- •8. Females receiving Hormone Replacement Therapy (HRT)
- •9. Taking medications which might be interfered with by the product (i.e. warfarin etc.)
研究者
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