Predictors of Respiratory Failure Requiring ICU Admission Among Hospitalized Patients With SARS-Cov-2 Infection
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- SARS-CoV-2 Pneumonia
- Sponsor
- University of Bologna
- Enrollment
- 350
- Locations
- 1
- Primary Endpoint
- Respiratory failure
- Last Updated
- 6 years ago
Overview
Brief Summary
The emergence of SARS-CoV-2 is currently engaging and consuming most of resources of efficient healthcare systems in Europe, and several hospitals are currently experiencing a shortage of ICU beds for critically-ill patients with SARS-CoV-2 pneumonia.
A risk stratification based on clinical, radiological and laboratory parameters seems necessary in order to better identify those patients who may need ICU admission and/or those who may benefit from a prompt antiviral therapy
Detailed Description
The study will compared patients with and without respiratory failure in order to find risk factors for need for ICU admission. A simple score based on risk factors will be created from a multicenter Italian cohort and validated in a multicenter international cohort.
Investigators
Michele Bartoletti
Assistant Professor
University of Bologna
Eligibility Criteria
Inclusion Criteria
- •Hospitalized patients with microbiologically confirmed diagnosis of SARS-CoV-2 infection
- •Age \> 17 years
Exclusion Criteria
- •Invasive mechanical ventilation within 12 hours from hospital admission
Outcomes
Primary Outcomes
Respiratory failure
Time Frame: 14 days
Composite of ICU admission or SpO2\<92% with 100% FiO2 of oxygen treatment (reservoir mask or CPAP or NIV), respiratory rate \>30 bpm, respiratory distress
Secondary Outcomes
- Occurence of bacterial superinfection(14 days)