Predictors of Respiratory Failure in SARS-Cov-2 Infection
- Conditions
- SARS-CoV-2 Pneumonia
- Registration Number
- NCT04316949
- Lead Sponsor
- University of Bologna
- Brief Summary
The emergence of SARS-CoV-2 is currently engaging and consuming most of resources of efficient healthcare systems in Europe, and several hospitals are currently experiencing a shortage of ICU beds for critically-ill patients with SARS-CoV-2 pneumonia.
A risk stratification based on clinical, radiological and laboratory parameters seems necessary in order to better identify those patients who may need ICU admission and/or those who may benefit from a prompt antiviral therapy
- Detailed Description
The study will compared patients with and without respiratory failure in order to find risk factors for need for ICU admission. A simple score based on risk factors will be created from a multicenter Italian cohort and validated in a multicenter international cohort.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 350
- Hospitalized patients with microbiologically confirmed diagnosis of SARS-CoV-2 infection
- Age > 17 years
- Invasive mechanical ventilation within 12 hours from hospital admission
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Respiratory failure 14 days Composite of ICU admission or SpO2\<92% with 100% FiO2 of oxygen treatment (reservoir mask or CPAP or NIV), respiratory rate \>30 bpm, respiratory distress
- Secondary Outcome Measures
Name Time Method Occurence of bacterial superinfection 14 days Incidence of bacterial superinfection among ventilated patients with SARS-CoV-2 pneumonia
Trial Locations
- Locations (1)
University of Bologna - Department of Medical and Surgical Sciences
🇮🇹Bologna, Italy