NCT03228355已完成不适用
The Effects of Levcromakalim on Cerebral Hemodynamic in Migraine Patients
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Headache
研究概览
简要总结
To investigate the role of KATP channels on the cerebral hemodynamic in migraine patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Migraine patients of both sexes.
- •18-60 years.
- •50-90 kg.
- •Women of childbearing potential must use adequate contraception.
排除标准
- •Headache less than 48 hours before the tests start
- •Daily consumption of drugs of any kind other than oral contraceptives
- •Pregnant or nursing women.
- •Cardiovascular disease of any kind, including cerebrovascular diseases.
研究组 & 干预措施
Levcromakalim
Active Comparator
干预措施: Levcromakalim (Drug)
Saline
Placebo Comparator
干预措施: Saline (Drug)
结局指标
主要结局
Headache
时间窗: Before (-10 min) and after infusion (+12 hours) of levcromakalim compared with before and after infusion of saline
Occurrence of headache.
Cerebral hemodynamic
时间窗: Before (-10 min) and after infusion (+2 hours) of levcromakalim compared with before and after infusion of saline
Change on Media cerebri arterie.
Migraine attack
时间窗: Before (-10 min) and after infusion (+12 hours) of levcromakalim compared with before and after infusion of saline
Occurrence
次要结局
未报告次要终点
研究者
Mohammad Al-Mahdi Al-Karagholi
MD, PhD student
Danish Headache Center
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Headache Inducing Effect of Levcromakalim in Migraine With Aura PatientsHeadacheAuraMigraineNCT04012047Danish Headache Center17
招募中
不适用
Headache Inducing Effect of NN414 in Migraine PatientsHeadache, MigraineNCT04744129Danish Headache Center16
已完成
不适用
Migraine Inducing Effect of Levcromakalim in Patients With Migraine With AuraHeadache, MigraineAuraNCT04905654Danish Headache Center35
招募中
不适用
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.HeadacheMigraine Without AuraMigraine With AuraNCT05565001Danish Headache Center20
Unknown
不适用
The Hemodynamics Effect of Glibenclamide on Levcromakalim Assessed by High Resolution Magnetic Resonance Angiography (MRA) Technique in a Randomized Double-blind Cross-over Placebo-controlled Study With Healthy VolunteersHemodynamics of Cranial ArteriesHeadacheCerebral Blood FlowNCT03886922Danish Headache Center15