Search for Genetic Basis of Vulvodynia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 168
- 试验地点
- 1
- 主要终点
- Genetic association of Vulvodynia
研究概览
简要总结
The purpose of this study is to investigate the possibility of an association between Localized Provoked Vulvodynia (LPV) that is both severe and primary and polymorphic markers/single nucleotide polymorphisms (SNPs) in and around the genes encoding heparanase (HSPE-1), Vanilloid Receptor VR1 (TRPV1), and Nerve Growth Factor (NGF).
详细描述
The short-term goal proposed for the current study was to investigate the possibility of an association between Localized Provoked Vulvodynia (LPV) that is both severe and primary and polymorphic markers/single nucleotide polymorphisms (SNPs) in and around the genes encoding heparanase (HSPE-1), Vanilloid Receptor VR1 (TRPV1), and Nerve Growth Factor (NGF).
Eight polymorphic SNPs in the three different genes suspected to be involved in LPV has been examined as follow:
- HSPE gene: Four polymorphic SNPs: rs4693608, rs11099592, rs6856901 and rs4364254 that were found to be informative in the Ashkenazi Jewish population
- TRPV1 gene: Two polymorphic SNPs: rs222747 and rs8065080.
- NGF gene: A novel T to C SNP in the promoter region at position -198 (rs11102930) and rs6330 which was found to be associated with anxiety-related personality traits and has been suggested to may affect intracellular processing and secretion of NGF.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •o meeting Friedrich's criteria [50] for vulva vestibulitis syndrome
- •diagnosed by a gynecological examination with LPV
- •diagnosed with a severe degree of the syndrome according to Marinoff [48]
- •classified with the primary type of the syndrome according to an interview
- •with both parents of Ashkenazi origin.
排除标准
- 未提供
结局指标
主要结局
Genetic association of Vulvodynia
时间窗: four years
the possibility of an association between Localized Provoked Vulvodynia (LPV) that is both severe and primary and polymorphic markers/single nucleotide polymorphisms (SNPs) in and around the genes encoding heparanase (HSPE-1), Vanilloid Receptor VR1 (TRPV1), and Nerve Growth Factor (NGF).
次要结局
未报告次要终点
研究者
Prof. Jacob Bornstein
Principal Investigator
Western Galilee Hospital-Nahariya