Vitamin D supplementation in infertile males with decreased sperm count and motility.
Not Applicable
- Conditions
- Health Condition 1: null- Infertility
- Registration Number
- CTRI/2017/09/009678
- Lead Sponsor
- ESI PGIMSR
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1) Infertile males meeting the WHO criteria for oligospermia or asthenozoospermia, i.e. sperm concentration <15 million/ml and/or progressive sperm motility <32%.
2) Males asymptomatic for vitamin D deficiency.
Exclusion Criteria
1) Men with history of any chronic illness, endocrine or metabolic disorders or malignancy.
2) History of intake of vitamin D for preceding 3 months.
3) History of testicular infection, testicular mumps, cryptorchidism, varicocelectomy, testicular biopsy.
4) Males with vitamin D level > 30 ng/ml
5) Males with azoospermia.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1) Semen parameters- sperm concentration, sperm motilityTimepoint: 3 months
- Secondary Outcome Measures
Name Time Method ) Levels of reproductive hormone profile- FSH, LH, Testosterone, Estradiol. <br/ ><br>2) Levels of bone regulating hormones- Alkaline phosphatase, serum calcium, serum phosphate. <br/ ><br>3) Effect on pregnancy outcomes <br/ ><br>Timepoint: 6 months