ong-term Effects of selective fetal growth restriction in MONochorionic twins
- Conditions
- Selective fetal growth restriction (sFGR), monochorionic twins.
- Registration Number
- NL-OMON24670
- Lead Sponsor
- eiden University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 132
To be eligible to participate in this study, a subject must meet all the following criteria:
• MC twins with sFGR born in the LUMC.
• Children aged 2 to 17 years at time of inclusion.
• Children currently living in the Netherlands.
The parents of a potential subject must meet the following criteria:
• Parent(s) aged = 18 years, who are able to consent.
• Written informed consent from both parents to participate, form being approved by the Ethic Committee.
A potential subject who meets any of the following criteria will be excluded from participation in this study:
• MC twins with TTTS or TAPS.
• Twin Reversed Arterial Perfusion (TRAP).
• Monoamniotic twin pregnancies.
• Children passed away before inclusion.
• Single survivors.
• Children born with congenital/chromosomal abnormalities.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The project addresses five primary objectives:<br>I. To assess long-term neurodevelopmental outcome using cognitive tests<br>II. To assess long-term cardiovascular outcome using cardiac ultrasound<br>III. To assess long-term pulmonary outcome using spirometry<br>IV. To assess long-term growth by evaluating childhood growth patterns<br>V. To assess long-term (epi)genetic changes by evaluating DNA methylation patterns in buccal swabs<br>These outcomes will be examined in a large cohort of MC twins with sFGR and compared between the small and the large twin.
- Secondary Outcome Measures
Name Time Method