Exploring Biomarkers in Age Stratified PUMCH Dementia Cohort
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 2,000
- 试验地点
- 1
- 主要终点
- Incorporating age stratified biomarkers into the diagnosis of dementia
研究概览
简要总结
Biomarkers are important for early and precise diagnosis of dementia. However, the causes of dementia in different age are different. We designed an age stratified dementia cohort and tried to explore biomarkers of different groups of dementia, incorporating neuropsychology, multi-model neuroimaging, metabolics and proteomics based fluid biomarkers as well as genetic biomarkers. Autopsy after clinical follow up help to verify the biomarkers.
详细描述
Baseline data collection and cohort establishing: Detailed clinical information including demographic data, clinical history, past history and physical examination are collected. Formatted neuropsychological battery is used in all patients, including screening tests (MMSE, MoCA-PUMCH, ADL, HAD) and domain specific evaluation (Memory, executive function, visual spatial, calculation, language). Samples including serum, CSF, urine, skin, saliva are stored. Every patient is followed up every 6 months. Autopsy brain tissue will be collected if patients died.
Multi-model neuroimaging evaluation: Structure and functional brain 3T-MRI; 7T-MRI； PET-CT including FDG, Aβ（18F-AV45）,tau（18F-THK5317, 18F-T807）; EEG
Multi-omics biomarkers research:
CSF AD biomarkers (Aβ40,42, ptau181, ttau, NfL, Neurogranin), comparison of different methods, including ELISA, Electrochemical, Mass Spectroscopy. The standardization of CSF biomarkers analysis in China.
Exploring new fluid biomarkers: CSF and Urine proteomics; CSF and serum glycomics and metabolomics. To explore new biomarkers in differentiation of different causes of dementia, age onset and prognosis of dementia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Neurodegenerative dementia diagnosis based on 2011 NIA-AA criteria of Dementia
- •Fixed care giver and can follow up regularly
排除标准
- •Not demented, including MCI
- •Systemic severe diseases and severe vision or hearing problem effecting follow up and neuropsychological evaluation
- •Without fixed care giver
- •Reject informed consent
- •Expected life shorter than 2 years
结局指标
主要结局
Incorporating age stratified biomarkers into the diagnosis of dementia
时间窗: Through study completion,an average of 5 years
Comparing the relationships between biomarkers and clinical presentations as well as neuroimaging. Incorporate biomarkers into the accurate and early diagnosis of dementia
次要结局
- Establishing dementia cohort including detailed clinical information, fluid samples and brain bank(Through study completion,an average of 5 years)
- Exploring 5-10 kinds of age stratified biomarkers, including neuropsychology, neuroimaging, fluid biomarkers and genetic biomarkers(Through study completion,an average of 5 years)
研究者
gaojing
Professor, Department of Neurology
Peking Union Medical College Hospital