correlation of standard radiation dose delivered with symptoms of the patient
Not Applicable
- Conditions
- Health Condition 1: C719- Malignant neoplasm of brain, unspecified
- Registration Number
- CTRI/2021/04/032897
- Lead Sponsor
- MPMMCC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Histopathological tissue diagnosis of high-grade glioma
2.KPS >=70
3.Age >18 and <70 Yrs
4.Fit to receive radiotherapy
5.Has undergone definitive Surgery
6.Willing to fill informed consent form
Exclusion Criteria
1.Any prior history of radiation to brain
2.Age less than 18yrs or more than 70 yrs
3.Any KPS <70
4.Low grade gliomas
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Tumor response (RANO criteria) <br/ ><br>2.Change in edema volume at pre-RT, 3, 6, 12, 18- and 24-months post radiotherapy <br/ ><br>3.Grade of symptoms and QOL scores at pre-RT, 3, 6, 12, 18- and 24-months post radiotherapy. <br/ ><br>4.Disease free Survival, 1-year survival and 2-year survival. <br/ ><br>5.3 yr OS <br/ ><br>Timepoint: 1.Tumor response (RANO criteria) <br/ ><br>2.Change in edema volume at pre-RT, 3, 6, 12, 18- and 24-months post radiotherapy <br/ ><br>3.Grade of symptoms and QOL scores at pre-RT, 3, 6, 12, 18- and 24-months post radiotherapy. <br/ ><br>4.Disease free Survival, 1-year survival and 2-year survival. <br/ ><br>5.3 yr OS <br/ ><br>
- Secondary Outcome Measures
Name Time Method nillTimepoint: nill