The Effect of Retro Walking on Pain and Gait Biomechanics Using Non-linear Analysis in People With Knee Osteoarthritis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 44
- 主要终点
- Knee function and associated frequency and severity of pain
研究概览
简要总结
Knee osteoarthritis, a chronic musculoskeletal disease, is the most prevalent type of osteoarthritis and the leading cause of disability and major healthcare costs worldwide. The pathogenesis of the disease is not fully understood and there are few non-invasive disease-modifying therapies available to patients. Therefore, there is a critical need to enhance therapeutic interventions, which requires improvement of our understanding of knee osteoarthritis pathogenesis.
Increasing evidence suggests that physical activity and exercise training are cost-effective and widely available interventions for the treatment of knee osteoarthritis, however, consideration of type of physical activity and optimal exercise modality are needed to reduce pain, improve gait, knee joint function, stiffness, and muscle weakness in individuals with knee osteoarthritis.
The aim of this pilot clinical trial is to compare individuals with knee osteoarthritis who have not exercised with individuals that have performed retro walking exercise chosen from the systematic review and survey we have conducted previously to reduce pain and improve gait.
Non-linear analyses will be performed to determine the effects of exercise intervention on gait biomechanics and stability of movement in these patients. These findings may form a basis for recommendations of exercise/physical activity interventions for the benefits of patients with knee osteoarthritis including pain reduction, mobility improvement and gait modification.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male and female
- •Any ethnicity
- •Adults over 18 years old
- •Meet the UK guidelines for physical activity supported by NICE (National Institute for Health and Care Excellence) and NHS (able to exercise if it is safe with regular breaks)
- •Otherwise, adults with clinically diagnosed knee osteoarthritis according to NICE criteria or confirmed by a healthcare professional able and willing to participate and provide written informed consent
排除标准
- •Any musculoskeletal injury
- •Any conditions known to affects gait (e.g. Parkinson's disease or stroke)
- •Any surgical intervention in the previous 12 months on lower limbs
- •Surgical replacement of hip or knee joints
- •BMI (body mass index) over 35
- •Athletes or take part in significant recreational activity
- •Takes any medication known to affect the gait and ability to walk
- •Received an intra-articular injection in the last 3 months
- •Have been told by medical professionals that they should not take part in any intensity exercise/physical activity
研究组 & 干预措施
Exercise
Participants in the intervention group will perform treadmill retro walking exercise 3 days/week for 6 weeks.
干预措施: Retro walking (backwards walking) on a treadmill (Other)
Control
Participants in the control group will maintain their existing level of activity.
结局指标
主要结局
Knee function and associated frequency and severity of pain
时间窗: Baseline or Day 1 and end of study at 6 weeks
Participants' opinion about their own knee function and associated problems will be assessed through self-administered and validated questionnaire Knee Injury and Osteoarthritis Outcome Score (KOOS). KOOS questionnaire designed to collectively evaluate and measure five outcomes in individuals with knee osteoarthritis including: Pain: Frequency and severity of knee pain. Symptoms: Swelling, grinding, stiffness, and range of motion issues. Activities of Daily Living (ADL): Difficulty with physical tasks like stairs, rising from a seat, or getting in and out of a car. Sports and Recreation Function: The ability to perform higher-level physical activities, such as running, squatting, or playing sports. Quality of Life (QOL): Knee-related lifestyle limitations and personal awareness of the joint.
次要结局
- Pain intensity(Baseline or Day 1 up to 6 weeks)
- The gait biomechanics - change from baseline in spatiotemporal parameter walking speed at 6 weeks(Baseline or Day 1 and end of study at 6 weeks)
- The gait biomechanics - change from baseline in spatiotemporal parameter cadence at 6 weeks(Baseline or Day 1 and end of study at 6 weeks)
- The gait biomechanics - change from baseline in spatiotemporal parameter stride/step length at 6 weeks(Baseline or Day 1 and end of study at 6 weeks)
- The gait biomechanics - change from baseline in spatiotemporal parameter swing/stance phases at 6 weeks(Baseline or Day 1 and end of study at 6 weeks)
- The gait biomechanics - change from baseline in spatiotemporal parameter double support time at 6 weeks(Baseline or Day 1 and end of study at 6 weeks)
- The gait biomechanics - change from baseline in kinetic parameter knee adduction moment (KAM) at 6 weeks(Baseline or Day 1 and end of study at 6 weeks)
- The gait biomechanics - change from baseline in kinetic parameter knee flexion/extension moment at 6 weeks(Baseline or Day 1 and end of study at 6 weeks)
- The gait biomechanics - change from baseline in kinetic parameter vertical ground reaction force (vGRF) at 6 weeks(Baseline or Day 1 and end of study at 6 weeks)
- The gait biomechanics - change from baseline in kinetic parameter joint contact force (JCF) at 6 weeks(Baseline or Day 1 and end of study at 6 weeks)
- The gait biomechanics - change from baseline in kinematic parameter knee flexion angle at 6 weeks(Baseline or Day 1 and end of study at 6 weeks)
- The gait biomechanics - change from baseline in kinematic parameter Range of Motion (ROM) at 6 weeks(Baseline or Day 1 and end of study at 6 weeks)
- The gait biomechanics - change from baseline in kinematic parameter knee adduction/abduction at 6 weeks(Baseline or Day 1 and end of study at 6 weeks)
- Gait stability(Baseline or Day 1 and end of study at 6 weeks)