Dopaminergic mechanisms of gating working memory, learning, and motivation: A pharmaco-fMRI study

Recruiting

• Conditions: distractibility; lack of motivation; 10009841

• Registration Number: NL-OMON52146
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 46

Inclusion Criteria

- Healthy volunteers between 18-45 years of age.
- Right-handed

Exclusion Criteria

Neuropsychiatric disorders; history of drug abuse; heart problems; metal
objects in or around the body (see section 4.3 in the Research Protocol C1 for
full list of exclusion criteria).

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Behaviour on cognitive tasks (working memory, reward learning & perceptual<br /><br>decision making, and effect of motivation on cognitive control), and associated<br /><br>physiological measures:<br /><br>• working memory: BOLD signal (measured with fMRI)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p> Our secondary aim is determine how relevant interindividual differences<br /><br>(impulsivity, working memory capacity) may moderate drug effects. For this we<br /><br>will assess the relationship of behavioural performance on computerized tasks<br /><br>(as above) with i) subjective measurements (self-report questionnaires); ii)<br /><br>performance on neuropsychological tests (WM capacity</p><br>