Comparison of vitamin C plus blood protein derivative & blood protein derivative in treatment of bone loss seen in posterior teeth

Phase 4

Not yet recruiting

• Conditions: Chronic periodontitis,

• Registration Number: CTRI/2023/07/054656
• Lead Sponsor: DR TUSHARIKA SHARMA

Brief Summary

Periodontitis is aninflammatory destructive disorder of the periodontal supporting structures,which is associated with microbial dysbiosis. Its primary features include theloss of periodontal tissue support , manifested through clinical  attachmentloss , presence of periodontal pocket and radiographically alveolar  boneloss. The goal  of  regenerative periodontal therapy, is to restorethe tooth supporting apparatus that has benn lost due to periodontal disease orinjury . PRF is classified as a second generation platelet concentrate, as itis prepared as a natural concentrate without the addition of anyanticoagulants. Platelet rich fibrin  is an easily prepared , autologousnatural scaffold  harbouring a multitude of growth /differentiationfactor. Vitamin C may lower the risk of periodontal diseases and evenfacilitate  healing  of the periodontium due to its strongantioxidant capacity that allows it to inactivate ROS that  damagestructure and function of tissues.Surgical procedure is done after presurgicaltreatment ,that is scaling and root planning. After oral prophylaxis is done ,1 week follow up is done . After 1 week clinical parameters to be evaluated andsurgery is performed in which OFD  with PRF  is done on one side andon the other side OFD  alongwith  ascorbic acid and PRF is injectedon other side. Then flaps are approximated and then sutured . After thatclinical and radiographic parameters are evaluated at 3 months and 6 months.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-07-08
• Last Update Posted: 2023-10-06

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Age group between twenty five years to sixty years Willing to participate in study.
• Availability for follow-up appointments Patients with mandibular molars and grade II furcation.
• Clinical attachment loss more than or equal to 5 mm Probing depth more than or equal to 6 mm Radiographic intraosseous defect more than or equal to 3 mm Systemically healthy.

Exclusion Criteria

• Pregnant or lactating mothers.
• Patients with known systemic disease or blood dyscrasias or on any medication known to interfere with outcomes of periodontal therapy.
• Current smokers, tobacco chewers and alcoholic patients.
• Previously treated for periodontal disease within 6 months.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Radiographic bone level,	Baseline | 3 Months | 6 Months
Radiographic bone defect fill percentage	Baseline | 3 Months | 6 Months

Secondary Outcome Measures

Name	Time	Method
Probing Pocket Depth,	Plaque index,

Trial Locations

Locations (1)

Km Shah Dental College; 🇮🇳 Vadodara, GUJARAT, India

Km Shah Dental College

🇮🇳Vadodara, GUJARAT, India

Dr Tusharika Sharma

Principal investigator

8082864187

tusharika4064@gmail.com