Comparing the effectiveness of Ciprofloxacin, Ceftriaxone, and Gentamicin for preventing bacteriuria after transurethral lithotripsy (TUL)

Not Applicable

Recruiting

• Conditions: Comparing the effectiveness of ciprofloxacin, ceftriaxone, and gentamicin for preventing bacteriuria after transurethral lithotripsy.

• Registration Number: IRCT20231031059918N1
• Lead Sponsor: Yazd University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 264

Inclusion Criteria

Patients with middle and distal ureteral calculi with negetive urine culture that are going to undergo TUL (the maximum diameter of the stone is <2 cm)
Age 18 to 65 years old.

Exclusion Criteria

Asymptomatic patients with colony count = 10 5 CFU/mL or a symptomatic UTI with colony count = 10 3 CFU/mL
Patients with any catheter.
Patients with preoperative fever (body temperature = 38°C)
Patients with a history of diabetes.
Patients with immunocompromised diseases or using immunosuppressive drugs
Patients with abnormal renal function
Patients who have received antimicrobial treatment within two weeks before enrollment
Pregnant or breastfeeding women
Patients who are allergic to our research drugs.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Significant bacteriuria was defined asymptomatic patients with colony count = 10 5 CFU/mL or a symptomatic UTI with colony count = 10 3 CFU/mL. Timepoint: After 48 hour of surgery, routine urine tests and urine bacterial cultures, will be recorded. Method of measurement: Routine urine tests and urine bacteria culture are done in the Rahnemoun hospital laboratory.;Febrile urinary tract infection (fUTI) is defined as a body temperature of 38.5 C accompanying urinary tract infection after surgery. Timepoint: After 48 hour of surgery. Method of measurement: body temperature by thermometer will be recorded.;•SIRS criteria defined by: WBC < 4000 or > 12000 , heart rate > 90 per minute , temperature < 36 C or > 38 C , respiratory rate >20 or pCO2 < 32 . (Presence of two or more of these criteria is accepted as SIRS.). Timepoint: After 48 hour of surgery. Method of measurement: Routine urine tests and urine bacteria culture are done in the Rahnemoun hospital laboratory.