Prospective observational study to investigate the long-term course of MR-guided percutaneous tumor ablation of primary or secondary liver or kidney tumors

Recruiting

• Conditions: C64; C22; Malignant neoplasm of liver and intrahepatic bile ducts; Malignant neoplasm of kidney, except renal pelvis

• Registration Number: DRKS00026171
• Lead Sponsor: niversitätsklinikum Tübingen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-08-23
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Patients who have clinically indicated tumor ablation for primary or secondary liver or kidney tumors.
- The indication for percutaneous tumor ablation takes place in an interdisciplinarytumor conference.
- Completion of the age of 18 and the patient's legal capacity to give consent.
- Concomitant diseases or adjuvant chemotherapy or previous therapy using transarterial chemotherapy or other ablation procedures do not constitute exclusion criteria for participation in the study.

Exclusion Criteria

- Missing or incomplete declaration of consent from the patient.
- Minor patients.
- Pregnant / breastfeeding women.
- Patients incapable of giving consent.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prospective data collection on 300 MR-guided tumor ablation procedures (with regard to the intervention and the follow-up) and quality assurance.

Secondary Outcome Measures

Name	Time	Method
- Assessment of the clinical benefit and effectiveness of different approved MR-guided tumor ablation procedures:<br>- Thermoblation process: radio frequency, microwave, laser and Cryoablation and the high-intensity focused ultrasound,<br>- Non-thermal tissue ablation method: irreversible electroporation.<br>- Collection of data on overall survival, relapse-free survival, occurrence of local recurrences and complications.<br>- Optimization of the intervention protocols with regard to possible time reduction.<br>- Lesion-based evaluations using MRI.<br>- Investigation of influencing factors on the therapy result and the development of local recurrences.<br><br>