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临床试验/NCT07673198
NCT07673198尚未招募不适用

Word Retrieval in Aphasia

Albert Einstein Healthcare Network1 个研究点 分布在 1 个国家目标入组 12 人开始时间: 2026年8月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
尚未招募
入组人数
12
试验地点
1
主要终点
Trained naming items

研究概览

简要总结

Aphasia is a disorder of spoken and written language, most commonly following a stroke. It is estimated that between 2.5 and 4 million Americans are living with aphasia today. A common problem in aphasia involves difficulty retrieving known words in the course of language production and comprehension. The overarching goal of this project is to develop and test early efficacy, efficiency, and the tolerability of a lexical treatment for aphasia in multiple-session regimens that are comprised of retrieval practice, distributed practice, and training dedicated to the elicitation of correct retrievals. The aim of this work is to add to and refine the evidence base for the implementation and optimization of these elements in the treatment of production and comprehension deficits in aphasia, and make important steps towards an ultimate goal of self-administered lexical treatment grounded in retrieval practice principles (RPP) to supplement traditional speech-language therapy that is appropriate for People with Aphasia (PWA) from a broad level of severity of lexical processing deficit in naming and/or comprehension. This project cumulatively builds on prior work to develop a theory of learning for lexical processing impairment in aphasia that aims to ultimately explain why and for whom familiar lexical treatments work, and how to maximize the benefits they confer.

详细描述

This study examines a retrieval practice-based naming treatment termed criterion learning. In criterion learning, each item's assigned criterion level dictates the number of times that item is correctly retrieved before it is dropped from further training within a session. Criterion learning optimally incorporates potent learning experiences, including spaced retrieval practice with emphasis on correct retrievals during training. The present study will provide critical observations for optimizing criterion learning for treating word processing deficits in people with aphasia. This study will recruit 12 community-dwelling individuals with aphasia, who will undergo comprehensive neuropsychological characterization. Subsequently, participants will engage in an experimental treatment designed to promote improvements in word retrieval deficits.

This study will examine whether making retrieval practice more effortful by increasing semantically-driven lexical competition enhances naming treatment benefit in a multiple-session naming treatment. This involves training items amidst related (e.g., for "dog," horse, cow, zebra) or unrelated items (e.g., for "dog," ambulance, pencil, rose). Each PWA will complete multiple training/test rounds--a round refers to the two training sessions separated by one or more days, and a retention test for those items. In some sessions, a desk-mounted eyetracker will be used to track eyegaze patterns as participants name pictures.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 89 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • English as a native or primary language
  • Adults with stroke who are at least 6 months post-onset

排除标准

  • History of comorbid neurological diagnoses, such as Multiple Sclerosis or Parkinson's Disease
  • History of a learning disability that significantly impacted language development, such as developmental language disorder
  • Insufficient stamina to participate in the protocol

研究组 & 干预措施

Criterion-learning practice

Experimental

This is a single-arm study

干预措施: Criterion-learning practice (Behavioral)

结局指标

主要结局

Trained naming items

时间窗: approximately one-week following treatment

Confrontation naming task that involves trained items

次要结局

  • Trained naming items pupillometry(approximately one-week post-treatment)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Erica Middleton

Institute Scientist, Jefferson Moss Rehabilitation Research Institute

Albert Einstein Healthcare Network

研究点 (1)

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