Changes of Ocular Structures After Hemodialysis in Patients With Chronic Kidney Diseases

Completed

• Conditions: Chronic Kidney Diseases; Hemolysis
• Interventions: Other: ophthalmologic exams

• Registration Number: NCT03434145
• Lead Sponsor: Hanyang University

Brief Summary

To evaluate the effect of hemodialysis on various ophthalmologic parameters in patients with end-stage kidney disease (ESRD).

Detailed Description

Subjects: patients with ESRD undergoing hemodialysis at the Dialysis Center of Hanyang Guri Hospital

Ocular parameters: visual acuity, intraocular pressure, axial length, OCT Other systemic parameters: body weight, ultrafiltration volume, and systolic/diastolic blood pressure

All measurements were performed near the dialysis center. Measurements were performed on Monday (for patients who underwent dialysis sessions on Monday, Wednesday, and Friday) or Tuesday (for patients who underwent dialysis sessions on Tuesday, Thursday, and Saturday.

All parameters were measured before and after the hemodialysis.

Study Timeline

• Study Start: 2016-09-09
• Primary Completion: 2017-09-07
• Study Completion: 2017-12-29
• Status Verified: 2018-02
• Study First Submitted: 2018-02-05
• Study First Submitted QC: 2018-02-08
• Last Update Submitted: 2018-02-08
• Study First Posted: 2018-02-15
• Last Update Posted: 2018-02-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• 1. patients who are regularly dialyzed in our dialysis room to participate in the study
• 2. patients who agree with our study protocol
• 3. patients who have unstable general condition

Exclusion Criteria

• 1. previous intraocular surgery, (2) baseline IOP greater than 22 mmHg, (3) presence of glaucomatous optic disc changes including excavation, thinning, or notching of the neuroretinal rim, (4) axial length greater than 26 mm, and (5) combined macular and retinal diseases such as central serous chorioretinopathy and age-related macular degeneration, except diabetic retinopathy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
patients with chronic kidney diseases	ophthalmologic exams	patients with end stage retinal disease undergoing hemodialysis underwent various ophthalmologic exams before and after hemodialysis.

Primary Outcome Measures

Name	Time	Method
changes of retinal and choroidal thickness after hemodialysis	immediately (within 10 minutes) before and after hemodialysis	retinal \& choroidal thickness on OCT

Secondary Outcome Measures

Name	Time	Method
the effect of hemodialysis (HD) on anterior chamber angle by anterior segment optical coherence	immediately (within 10 minutes) before and after hemodialysis	intraocular pressure, retinal thickness, anterior chamber angle
changes of foveal vascular density using optical coherence tomography-angiography (OCTA) after hemodialysis	immediately (within 10 minutes) before and after hemodialysis	vessel density on OCTA