Effect of Adipose Derived Stem Cells on Survival of Fat as Filler
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Assessment using hollowness severity rating scale :0 : no visible hollowness, 1: mild Hollowness, 2 : moderate Hollowness, 3: severe Hollowness
研究概览
简要总结
this research is to study the effect of Adipose Derived Stem Cells on Survival of Fat as Filler
详细描述
Skin aging is a complex biological process.The physiological changes associated with aging of the skin are manifested in xerosis, dramatic loss of skin elasticity due to damage to collagen and elastin fibers; as well as barrier function, modification of rhytides and deficiencies in the regenerative property of the skin. All of which ultimately result in thinning of the skin, malar fat atrophy and pigmentary changes. Autologous fat grafting or lipo injection containing stromal vascular fraction (SVF) acts like ideal soft tissue filler for facial filling and rejuvenation. It leads to progressive improvement of the skin texture, elasticity, and color over a few months, therefore adipose tissue seems to be not only a simple filler but also a dynamic filler with two types of different and supplementary effects, the volumetric effect and the regenerative effect.Cell assisted lipotransfer (CAL) is a technique that combines aspirated fat with concentrated ADSCs in the stromal vascular fraction (SVF) of the lipoaspirate. This technique could enhance the survival rate of the transplanted fat and leads to better cosmetic improvement
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •History of keloid formation.
- •Any coincidental chronic illness (e.g. metabolic, autoimmune or endocrinal) or malignancy.
- •Any bleeding or coagulation disorder or recent use of anticoagulant therapy.
- •Active infection.
- •History of any previous aesthetic procedure on the face within the past 6 months.
- •History of intake of anti-aging systemic or topical medications within the previous 3 months
研究组 & 干预措施
lipofilling
subcutaneous injection of lipoaspiate (microfat) in one temporal region
干预措施: lipofilling (Procedure)
lipofilling enriched with adipose tissue derived stem cells
subcutaneous injection of lipoaspiate enriched with adipose tissue derived stem cells in one temporal region
干预措施: lipofilling enriched with adipose tissue derived stem cells (Procedure)
结局指标
主要结局
Assessment using hollowness severity rating scale :0 : no visible hollowness, 1: mild Hollowness, 2 : moderate Hollowness, 3: severe Hollowness
时间窗: 3 months, 6 months
serial photography for assessment using hollowness severity rating scale :0 : no visible hollowness, 1: mild Hollowness, 2 : moderate Hollowness, 3: severe Hollowness
次要结局
- Measurement of hypodermal thickness in mm using UBM (Ultrasound Bio microscopy) on both temple regions of the head(3 months, 6 months)
- Measurement of dermal thickness in mm using UBM (Ultrasound Bio microscopy) on both temple regions of the head Measurement of dermal thickness in mm using UBM (Ultrasound Bio microscopy) on both temple regions of the head(3 months, 6 months)
研究者
Aliaa Ismail Ali Ismail
principle investigator
Alexandria University