Development of Bone Grafts Using Adipose Derived Stem Cells and Different Scaffolds
Completed
- Conditions
- Overweight
- Registration Number
- NCT01218945
- Lead Sponsor
- University of Zurich
- Brief Summary
The repair of large osseous defects remains still unsolved. Aim of this study is to isolate and cultivate fat-derived progenitor cells and differentiation into osteoblasts. Therefore, our research idea is to pre-engineer large synthetic bone grafts and study the vascularization process in vivo.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 33
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular pathways are involved in adipose-derived stem cell osteogenic differentiation for bone grafts?
How do pre-engineered capillaries in synthetic bone grafts affect vascularization and bone regeneration outcomes?
What are the comparative effectiveness of adipose-derived stem cells versus bone marrow-derived stem cells in critical size bone defect repair?
Which biomarkers can predict successful engraftment and osteoblastic differentiation of adipose-derived stem cells in vivo?
What are the potential adverse events associated with adipose-derived stem cell-based bone grafts and how can they be mitigated?
Trial Locations
- Locations (1)
University Hospital Zurich, Clinic of Reconstructive Surgery
🇨🇭Zurich, ZH, Switzerland
University Hospital Zurich, Clinic of Reconstructive Surgery🇨🇭Zurich, ZH, Switzerland