Dose Low Dose Ketamine in Casesarian

Not yet recruiting

• Conditions: Postoperative Pain; Postpartum Depression
• Interventions: Drug: Application of ketamine and midazolam or ketamine alone to patients undergoing cesarean section under spinal anesthesia

• Registration Number: NCT06237569
• Lead Sponsor: Inonu University

Brief Summary

The results of ketamine, ketamine and midazolom and placebo can be copied after birth in cesareans subjected to spinal anesthesia.

Detailed Description

Postpartum depression will be evaluated by dividing the patients into 3 groups: group 1 as ketamine, group 2 as ketamine and midasom, and group 3 as placebo group.

Study Timeline

• Status Verified: 2024-01
• Study First Submitted: 2024-01-12
• Study First Submitted QC: 2024-01-24
• Last Update Submitted: 2024-01-24
• Study First Posted: 2024-02-01
• Last Update Posted: 2024-02-01
• Study Start: 2024-06-01
• Primary Completion: 2024-08-01
• Study Completion: 2024-09-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Female
• Target Recruitment: 150

Inclusion Criteria

American Society of Anesthesiologists 2-.3 18 -45years old Patients planned to be born by cesarean section The patient requests a cesarean section with spinal anesthesia

ExclusionCriteria:

Pathological obstetric complications

Hypertension

Contraindication for ketamine Contraindication for spinal

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Grup 1 -Ketamine Group	Application of ketamine and midazolam or ketamine alone to patients undergoing cesarean section under spinal anesthesia	Ketamine Group (GROUP 1) 0.5 mg/kg IV single dose bolus diluted to 5 ml with 0.9% saline
Group 2-ketamine + midazolam	Application of ketamine and midazolam or ketamine alone to patients undergoing cesarean section under spinal anesthesia	Midazolam 0.0125 mg/kg is given followed by a single IV bolus dose of 0.5 mg/kg diluted to 5 ml with 0.9% saline.
Group 3-placebo	Application of ketamine and midazolam or ketamine alone to patients undergoing cesarean section under spinal anesthesia	Group 3-placebo ;A single dose of IV 5 ml physiological saline will be given.

Primary Outcome Measures

Name	Time	Method
postpartum depression	4 weeks	Reducing postpartum depression with low-dose ketamine
intraoperative complications	1 day	Reducing postpartum depression by reducing ketamine-related intraoperative complications
postoperative pain	1 day	Reducing postoperative pain with low dose ketamine

Trial Locations

Locations (1)

Inonu universitesi; 🇹🇷 Malatya, Turkey