Effects of Non Invasive Vagus Nerve Stimulation on Heart Rate Variability in Healthy Subjects and on Muscle Sympathetic Nerve Activity
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Autonomic Nervous System
- Sponsor
- Université Catholique de Louvain
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Heart rate variability modulation
- Last Updated
- 6 years ago
Overview
Brief Summary
To demonstrate the effect of non invasive vagus nerve (VNS) stimulation on heart rate variability and MSNA signal.
Detailed Description
First part: Assessment of the muscle sympathetic nerve activity (MSNA) at baseline using microneurography performed on the superficial peroneal nerve. Second part: Acquisition of the MSNA signal during non-invasive VNS and apnea. Non-invasive VNS is performed using several frequencies of stimulation. Maximal and voluntaries apnea are performed at the end of the expiration. Continuous recording of the following parameters: * non-invasive arterial blood pressure * R-R interval * electrocardiogram * MSNA activity * respiratory curve signal * respiratory rate, oxygen saturation
Investigators
Eligibility Criteria
Inclusion Criteria
- •Healthy volunteers
- •\>18 years old
Exclusion Criteria
- •pregnancy and breastfeeding
- •alcool/energy drinks/coffee consumption, exertion 24h before the participation
Outcomes
Primary Outcomes
Heart rate variability modulation
Time Frame: 4 hours
Modulation of heart rate variability assessed through analysis of MSNA signal
Secondary Outcomes
- Non-invasive vagus nerve stimulation(4hours)
- Profile of response for MSNA(4 hours)