Effect of supplementation with Folinic Acid and Methionine on hypomethylation in children with Down syndrome

• Conditions: Down Syndrome; Human Genetics and Inherited Disorders - Down's syndrome

• Registration Number: ACTRN12605000302651
• Lead Sponsor: SDS Pathology

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-09-05
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Children with Trisomy 21

Exclusion Criteria

Major health problems for which they receive medication.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ormalisation of metabolic markers linked to hypomethylation[Assessed after 120 days of supplementation and again 30 days later to establish the degree of wash-out]

Secondary Outcome Measures

Name	Time	Method
Improved immunity, learning ability and general health.[This is measured throughout the trial on a daily basis by the parents (on supplied diary sheets) and on a weekly basis by the researcher (phonecalls to the parents).]