Feasibility of A Co-designed Lifestyle Intervention during Treatment for Advanced colorecTal cancEr: a single centre pilot study.

Queen's University Belfast0 个研究点目标入组 60 人2024年3月26日

概览

阶段: 未知
干预措施: 未指定
疾病 / 适应症: Advanced (unresectable and/or metastatic) colorectal cancer undergoing chemotherapy
发起方: Queen's University Belfast
入组人数: 60
状态: 进行中（未招募）
最后更新: 去年

暂无简介。

注册库

who.int

开始日期

2024年3月26日

结束日期

2026年7月1日

最后更新

去年

研究类型

Interventional

性别

All

发起方

•Main participants:
•1\. Age of at least 18 years.
•2\. Histologically\-confirmed unresectable Stage III or Stage IV adenocarcinoma of the colon or rectum.
•3\. Planned for systemic anti\-cancer treatment (SACT) with a 5\-flourouracil\-based regimen with palliative intent.
•4\. Greater than 12 weeks from any prior SACT.
•5\. Greater than 4 weeks from any prior major surgery and fully recovered.
•6\. ECOG performance status 0\-2 and anticipated life expectancy greater than 4 months.
•7\. Adequate haematological, renal and hepatic function to undergo standard of care SACT as assessed by treating oncologist.
•8\. Medical clearance by treating physician to undergo symptom\-limited muscle strength testing, physical function testing, and tailored resistance\-based exercise training.
•9\. Ability (i.e. sufficiently fluent) and willingness to effectively communicate with the Physical Activity and Nutrition Coach.

•1\. Significant cognitive impairment or co\-morbid conditions precluding participation in a resistance\-training programme as determined by the investigator.
•2\. Peripheral neuropathy \> grade 2\.
•3\. Unlikeliness to participate in a physical activity and nutrition intervention as determined by the investigator.
•4\. Patients undergoing adjuvant\-intent chemotherapy in the setting of radically treated oligometastatic hepatic disease.
•5\. Concurrent treatment for a second malignancy.
•6\. Treatment with any medications deemed by the investigator as likely to preclude participation in a resistance\-training programme.
•7\. Individual already participating in structured resistance\-training \= 2 days per week.
•No specific exclusion criteria for nominated friends/family members, healthcare professionals, and non\-participants taking part in questionnaires and interviews.