Food Innovation for Reduction of Carcinogen from Alcohol Drinking

Phase 2

Active, not recruiting

• Conditions: probiotic; alcohol-related cancer; milk; acetaldehyde; alcohol; carcinogen

• Registration Number: TCTR20210125003
• Lead Sponsor: Thailand Science Research and Innovation and Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-25
• Study Completion: 2021-01-29
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

1. Thai, 2. male, 3. age 20-50 years old, 4. normal vital signs, 5. no uncontrolled systemic diseases or autoimmune diseases, 6. normal blood chemistry (complete blood count, liver and kidney function, lipid and sugar), 7. active (1/*1) or inactive (1/*2) ALDH2 gene (10 subjects of each), 8. able to consume milk, 9. moderate alcohol drinking (less than 2 drinks per day or 14 drinks per week)

Exclusion Criteria

1. drinking alcohol during 1 week before the day of test, 2. having liver diseases (fatty lover, cirrhosis, hepatitis), gout, 3. history of gastrointestinal surgery, 4. alcoholism or alcohol abuse, 5. taking medicines affecting metabolism of alcohol including antibiotics, antidepressants, antihistamines, barbiturates, benzodiazepines, muscle relaxants, anti-inflammatory agents, anti-coagulants

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Salivary acetaldehyde 0, 5, 15, 30, 45, 60, 90, 120, 150, 210 min HPLC,Blood acetaldehyde 0, 5, 15, 30, 45, 60, 90, 120, 150, 210 min HPLC

Secondary Outcome Measures

Name	Time	Method
umber of LGG bacterial count in saliva 0, 5, 15, 30, 45, 60, 90, 120, 150, 210 min Selective culture