Dexmedetomidine Versus Triamcinolone Treatment of Carpal Tunnel Syndrome

Not Applicable

Completed

• Conditions: Carpal Tunnel Syndrome; Chronic Pain
• Interventions: Drug: Dexmedetomidine; Drug: Triamcinolone

• Registration Number: NCT04961281
• Lead Sponsor: Assiut University

Brief Summary

Carpal tunnel syndrome (CTS) is a common mononeuropathy due to entrapment of the median nerve in the carpal tunnel. a lot of modaleties are available for treatment of mild to moderate CTS.

Detailed Description

Carpal tunnel syndrome (CTS) is a common mononeuropathy due to entrapment of the median nerve in the carpal tunnel. a lot of modaleties are available for treatment of mild to moderate CTS.

In case of failed conservative oral therapey, local hydro-dessction of the median nerve can be done with saline alone. local anethetics, steroids, hyalase,and ozone have been utilized to augment the symptoms reliefe.

Dexmeditomidine (DEX) has been studied as adjuvant for nerve block to aumnet the pain reliefe. Recently, it has been discovered that DEX can offer some antinflammatory effects when injected in the perineural area. Upon such discovery, the goal of this study has been built.

Study Timeline

• Study First Submitted: 2021-06-22
• Study First Submitted QC: 2021-07-10
• Study First Posted: 2021-07-14
• Study Start: 2021-07-22
• Primary Completion: 2022-07-31
• Study Completion: 2022-08-01
• Status Verified: 2022-10
• Last Update Submitted: 2022-10-31
• Last Update Posted: 2022-11-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• adult patients
• complaining of carpal tunnel syndrome of 3 month duration or more
• diagnosed axonal neuropathy using electrodiagnosis , nerve conduction study

Exclusion Criteria

• patient refusal
• infection at the site of intervention
• allergy to utilized drugs
• diabetic
• previous surgery in the site of injection
• previous injection in the targeted site within the last year

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Dexmeditomidine group	Dexmedetomidine	injection of 1 microgram/kg dexmeditomidine + 10 cc saline injection nearby median nerve as hydro-dissection
triamcinolone group	Triamcinolone	injection of 40 mg triamcinolone + 10 cc saline injection nearby median nerve as hydro-dissection

Primary Outcome Measures

Name	Time	Method
pain visual analoge scale	6 months	visual analog scale of pain value of (0 cm) no pain , and value of (10 cm) worst pain

Secondary Outcome Measures

Name	Time	Method
change of cross sectional area of the median nerve	6 months	change of cross sectional area of the median nerve mm2

Trial Locations

Locations (1)

Emad Zarief Kamel Said; 🇪🇬 Assiut, Egypt