Physico Chemical Biological Characterization and Exploratory clinical trial of Abhrak Kalpa in the management of Silicosis

It is generally accepted that the pathogenesis of pulmonary fibrosis is characterized by persistent micro-damage to the alveolar epithelium with an abnormal repair process. This process is characterized by abnormal activation of myofibroblasts, excessive accumulation of ECM, and lung scar formation, ultimately leading to structural destruction and loss of lung function. [xv] Ayurveda prescribes a holistic approach to treating the disease or syndrome. Bioactive fractions from medicinal plants that treat multiple diseases could exert their effects by targeting common pathways. Hence, a definitive need is to introduce traditional formulation to combat silicosis, associated disorders, or the probable links with diseases. Silicosis has a complex disease; it is very tough to correlate with a single disorder in Ayurveda literature.