NL-OMON52739
Recruiting
Not Applicable
The search for biomarkers to enable detection and monitoring of disease progression from NAFLD to NASH and NASH itself; Amsterdam NASH cohort - Amsterdam NASH cohort (ANCHOR) study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Academisch Medisch Centrum
- Enrollment
- 300
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of steatosis hepatis on ultrasound or by biopsy or on Fibroscan
- •with CAP \>280dB/m
- •\>18 years of age
- •ASAT and/or ALAT levels above upper limit of normal in six months prior to
- •BMI \>25 kg/m2
Exclusion Criteria
- •Abusive alcohol use (\>20 IU/week)
- •Hepatitis B and/or C
- •Auto\-immune hepatitis
- •Wilsons disease/ alpha\-1\-antitripsine deficiency
- •Haemachromatose
- •Bleeding disorder, including the use of anticoagulant therapy and platelet
- •aggregation inhibitors. Except for subjects using platelet aggregation
- •inhibition monotherapy for the prevention of cardiovascular disease and without
- •a history of any coronary events. In this case the platelet aggregation
- •inhibitor will be discontinued for 7 days before the liver biopsy is performed.
Outcomes
Primary Outcomes
Not specified
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