Cognitive Remediation of Autobiographical Memory in Schizophrenia Using SenseCam®

Not Applicable

• Conditions: Schizophrenia Cognition Autobiographical Memory Cognitive Remediation
• Interventions: Device: Questionary

• Registration Number: NCT02038465
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

The aim of the study is to assess the efficiency of SenseCam® in patients with schizophrenia by comparing two cognitive remediation methods of autobiographical memory.Patients and control participants will be invited to carry SenseCam® during 7 hours per day minimum and for 4 successive days. Each ending day when carry SenseCam®, they will be asked to go to the laboratory where 4 types of interventions will be successively done according to the randomization: 1) a simple visual retrospective procedure (SVR), 2) a visual retrospective procedure coupled with a specific cueing intervention (VR-SC), 3) a verbal retrospective (VbR) and 4) no intervention (control condition).The testing phase will take place 14 days after the last day of data collection and will consist in a cued recall task and a recognition task using the pictures obtained by the SenseCam® of the participants.According to our hypotheses, the vividness of memories will be higher in events subjected to the VR-SC procedure than in events subjected to the SVR and VbR procedures. This effect is expected for both patients with schizophrenia and controls participants. Since strategies to enrich memory details will be explicitly given to the patients when using the VR-SC procedure, we assume that patients will be able to normalize their scores.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-06-25
• Study First Submitted QC: 2014-01-14
• Study First Posted: 2014-01-16
• Study Start: 2014-05
• Status Verified: 2018-08
• Last Update Submitted: 2018-08-24
• Last Update Posted: 2018-08-28
• Primary Completion: 2019-09
• Study Completion: 2019-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• for both patients and controls
• male or female willing to participate and who have signed up the legal document
• under the protection of health insurancefor patients only
• schizophrenia or schizo-affective disorder according to the DSM-IV
• TR criteria
• clinically stable for at least 2 monthsfor controls only
• no psychiatric history

Exclusion Criteria

• for both patients and controls
• current severe or unstable somatic illness
• neurological history (epilepsia, brain injury, brain surgery...)
• current substance use disorder (DSM-IV-TR)
• current major depressive disorder (DSM-IV-TR)
• mental retardation (IQ < 70)
• pregnancy, breast feeding
• current legal controlfor patients only
• treatment comprising benzodiazepines
• benzodiazepines intake during the last 3 weeksfor controls only
• psychotropic intake during the last 3 weeks

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
patient	Questionary	Complete questionary remembering the day
healthy volunteers	Questionary	- Complete questionary, remembering the day

Primary Outcome Measures

Name	Time	Method
Specificity of memories recovered by using the SenseCam camera during the trial	1 month	Test the effectiveness of two techniques of cognitive remediation of autobiographical memory using an innovative tool called SenseCam.This specificity will be evaluated by the experimenter by scoring wealth in detail memories reported during the cued recall task

Trial Locations

Locations (1)

Berna; 🇫🇷 Strasbourg, France