The effect of GTN patches on the maturation of arteriovenous fistulas

Phase 1

• Conditions: Arteriovenous fistulas for dialysis in renal failure; Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Therapeutic techniques [E02]

• Registration Number: EUCTR2012-003756-36-GB
• Lead Sponsor: niversity Hospital Birmingham NHS Foundation

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-03-14
• Last Update Posted: 27 July 2020

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

- Primary arteriovenous fistula - >18 yrs old - able to consent
Are the trial subjects under 18? no
Number of subjects for this age range: 0
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 150
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 50

Exclusion Criteria

All patients undergoing complex vascular access procedures will be excluded. - Patients with cardiovascular dysfunction including hypotension, obstructive cardiomyopathy, severe aortic stenosis and confirmed myocardial infarction within the last 6 months will be excluded. - Patients with marked anaemia - Patients with a history of migraine - Patients taking sildenafil or those already taking nitrates - Patients allergic to nitrates - Patients with closed-angle glaucoma - Patients with chronically raised intra-cranial pressure - Patients with a history of thyroid disease - Patients under 18 years old - Patients unable to give valid consent - Patients who are also prisoners

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified