The Effectiveness of Neurodynamic Mobilization in Carpal Tunnel Syndrome

Not Applicable

Not yet recruiting

• Conditions: Carpal Tunnel Syndrome (CTS); Median Nerve

• Registration Number: NCT06882707
• Lead Sponsor: Kutahya Health Sciences University

Brief Summary

This randomized, clinical, single-blinded, controlled study will initially planned to include 86 patients diagnosed with carpal tunnel syndrome who applied to Kütahya Health Sciences University, Evliya Çelebi Training and Research Hospital, Physical Medicine and Rehabilitation outpatient clinic and Kutahya City Hospital.Patients aged 20-55 years who were diagnosed with mild and moderate carpal tunnel syndrome by electromyography (EMG) in the last 6 months were included in the study. The patients were randomized into two groups using the computer-assisted randomization method. Median nerve mobilization and ultrasound therapy will be given to the study group, and only ultrasound therapy will be given to the control group. All the patients were evaluated with the Visual Analog Scale (VAS), Hand and Pinching Grip Test, Boston Carpal Tunnel Questionnaire (BCTQ) and Median Nerve and Abductor Pollicis Brevis Muscle ultrasonography before the intervention and at the third week of intervention.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-03
• Study First Submitted: 2025-03-12
• Study First Submitted QC: 2025-03-12
• Last Update Submitted: 2025-03-12
• Study Start: 2025-03-15
• Study First Posted: 2025-03-18
• Last Update Posted: 2025-03-18
• Primary Completion: 2025-06-15
• Study Completion: 2025-08-15

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 86

Inclusion Criteria

• Diagnosed with mild-to-moderate CTS on the dominant hand, based on the electrodiagnostic examination.
• Aged 20-55 years.
• Consent to receive the described treatment.
• Lasting symptoms at least 3 months

Exclusion Criteria

• A systemic inflammatory disease.
• Any disease that can cause polyneuropathy, for example, diabetes mellitus.
• A cognitive disorder.
• Receiving psychotherapy.
• A pacemaker.
• Any disease that can affect the central nervous system.
• Carpal tunnel syndrome surgery history

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
Ultrasound assessment	Change from Baseline at 3th weeks	The Median nerve's diameter will be evaluated bilaterally by another researcher blinded to interventions and experienced in musculoskeletal ultrasonography, using ultrasound with a 6-18 Mhz linear probe (Mindray-UMT 200, USA).; During the examination, patients will be seated on a stretcher, while the examiner sat on a higher stool.; The Median nerve will be evaluated by measuring the circumference of the nerve at the location where the nerve entered the carpal tunnel.; The ultrasound probe will be positioned above the epicondylus lateralis. The nerve cross-sectional area (CSA) will be recorded in the carpal tunnel while it was perpendicular to the wrist at 90 degrees on the Median nerve trace.; The nerve diameter will be measured from the circumference of the epineurium.

Secondary Outcome Measures

Name	Time	Method
Hand and pinching grip measurement	Change from Baseline at 3th weeks	The grip strength of the hand is measured with the Jamar hand dynamometer recommended by the American Association of Hand Therapists (AETD).; The measurement will be performed in the standard position specified by the AETD; the patient will be seated, shoulders in adduction and neutral rotation, elbow in 90 degree flexion, forearm in mid-rotation and supported, wrist in neutral position with three repetitions and the results will be recorded in kilograms.; Pinch force will be measured in the same position as the hand grip strength is measured with a pincmeter.; It will be evaluated in two different positions, lateral and triple grip. When evaluating the lateral grip, the patient will be asked to press the pinchmeter from the top with the middle of the distal phalanx of the thumb and support the lower part of the pinchmeter with the second phalanx of the index finger.; When evaluating the triple grip, measurements will be made by squeezing the thumb on one side of the pinchmeter an
Symptom severity and functional status	Change from Baseline at 3th weeks	Symptom severity and functional status were evaluated with BCTQ, a self-report measure of CTS with two domains: the Boston Carpal Tunnel Syndrome Questionnaire Symptom severity scale comprising 11 items to evaluate pain, paresthesia, and weakness and the Boston Carpal Tunnel Syndrome Questionnaire Symptom functional status domain with eight items assessing the ability to perform hand-related activities.; For each item, a high score indicates an increasing severity of symptoms or difficulty experienced.; The validity and reliability analyses of the Turkish version of BCTQ were undertaken by Sezgin et al19 Reliability of the Turkish version was very good, with high internal consistency (Cronbach's alpha 0.82 for symptom severity scale, and 0.88 for functional status scale), and reproducibility (Pearson correlation coefficient 0.60 for symptom severity scale, and 0.77 for functional status scale).

Trial Locations

Locations (1)

Kutahya Health Sciences University; 🇹🇷 Kutahya, Turkey