Efficacy of concomitant administration of nebulized lasix and salbutamol on spirometric indices of asthmatic patients
Phase 2
- Conditions
- Asthma.Asthma, unspecified
- Registration Number
- IRCT201104136187N1
- Lead Sponsor
- Vice chancellor for research, Kashan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 54
Inclusion Criteria
Asthma diagnosis based on signs of cough, sputum, intermittent and variable dyspnea, wheezing, and chest tightness for at least 6 months; diagnosis of asthma has been confirmed previously by specialists using following criteria: decline of FEV1/FVC, PEF, FEV1 and increasing FEV1>12% and >200ml after 15 min receiving short acting beta2 agonist or consuming corticosteroids orally for 2-4 weeks (prednisolone 30-40 mg daily). Among asthmatic patients only those who have persistent asthma (i.e. at least more than 2 nocturnal attacks per month and/or at least more than 2 daily attacks per week) are eligible cases.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method FEV1(forced expiratory volume in 1 second) improvment. Timepoint: 30 minute after nebulization. Method of measurement: Spirometry.;FVC(forced expiratory vital capacity) improvment. Timepoint: 30 minute after nebulization. Method of measurement: Spirometry.;MMEF(maximum midexpiratory flow) improvment. Timepoint: 30 minute after nebulization. Method of measurement: Spirometry.;Peak expiratory flow improvment. Timepoint: 30 minute after nebulization. Method of measurement: Spirometry.
- Secondary Outcome Measures
Name Time Method Bronchospasm. Timepoint: 30 minute after nebulization. Method of measurement: Clinical evaluation.