Sonography-guided Pericapsular Never Group Block for Hip Arthroplasty

Not Applicable

• Conditions: Analgesia; Nerve Block; Arthroplasty
• Interventions: Procedure: pericapsular nerve group block

• Registration Number: NCT04480320
• Lead Sponsor: Guangzhou First People's Hospital

Brief Summary

In this study, the investigator will examine the efficacy of Pericapsular nerve group (PENG) block in hip arthroplasty as a post-operative pain management technique, study the analgesia, opioid-sparing effects and motor-blocking effects of the PENG block

Detailed Description

PENG Block group (PG) will receive 0.5%Ropivacaine in 20 ml of saline. Sham Block group (SG) will receive 20 ml of saline Patient will be sedated with IV midazolam before nerve block. After peripheral nerve block ,general anesthesia will be conducted using sufentanyl, propofol and rocuronium for induction and propofol and sevoflurane for maintenance. Tests will be operated after procedure，and recorded up to 48 hours after surgery.

Study Timeline

• Study First Submitted: 2020-07-02
• Study First Submitted QC: 2020-07-16
• Study First Posted: 2020-07-21
• Status Verified: 2020-09
• Study Start: 2020-09-10
• Last Update Submitted: 2020-09-10
• Last Update Posted: 2020-09-14
• Primary Completion: 2021-03-31
• Study Completion: 2021-03-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 71

Inclusion Criteria

• Patients scheduled for hip arthroplasty

Exclusion Criteria

• allergy to local anesthetics
• infection at the injection site
• patients receiving opioids for chronic analgesic therapy
• other lower limb neuropathies
• inability to comprehend visual analog scale (VAS)
• preexist cognitive dysfunction

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Saline placebo group	pericapsular nerve group block	-
Pericapsular nerve group block	pericapsular nerve group block	-

Primary Outcome Measures

Name	Time	Method
Highest VAS score in recovery room	before recovery room discharge(up to 2 hours after surgery end)	Highest VAS score reported in recovery room,patient will be asked questions to measure the highest VAS score experienced in the recovery room before discharge. If the patient had a unexpected long stay at recovery room, the question will be asked at the time point "2 hours after surgery end"

Secondary Outcome Measures

Name	Time	Method
VAS at rest	day0 ,day1 ,day2	VAS pain score while patient at rest
highest VAS at period	day0 ,day1 ,day2	highest VAS reported at follow up period
quadriceps strength	day0 , day1 ,day2	Measure quadriceps strength peak value at different time point
total opioid consumption	up to 2 days after surgery
PONV rate	day0 ,day1 ,day2	postoperative nausea and vomit
Fall incident happened	up to 2 days after surgery	Record the fall incident happened,fall is defined as patinent accidently fall to the ground.
Nerve block range	day0 , before discharge from PACU(up to 2 hours after surgery end)	A cotton yarn with ethanol will be put on both the surgical and nonsurgical leg to evaluate the cold sensation lost after nerve block.Skin sensation lost will be tested at lateral thigh,medial thigh,front thigh and lateral claf

Trial Locations

Locations (1)

Guangzhou First Municipal People's Hospital; 🇨🇳 Guangzhou, Guangdong, China