The effect of probiotics on patients with end-stage renal failure

Phase 2

Conditions: Chronic kidney disease.
Chronic kidney disease (CKD)

Registration Number: IRCT20230608058421N1

Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 50

Inclusion Criteria

The age of entering the study is considered between 18 and 60 years.
Confirmation of chronic kidney failure from the patient's tests or documents that show a structural or functional disorder, or in other words, albuminuria or creatinine drop.
More than three months have passed since the mentioned disorders.
Affected patients should be under the same dialysis machines and similar filters.

Exclusion Criteria

History of kidney transplant
Any possible cause other than CKD for creatinine drop
Other causes of metabolic acidosis such as diarrhea, heart failure or shock
Metformin use
Taking blood pressure lowering medications due to the possibility of acidosis

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Arterial blood pH. Timepoint: Before intervention and 3 months after intervention. Method of measurement: Arterial blood gas measurement will be assessed by the optical method by the Edan device in the laboratory of Luqman Hakim Hospital.;Arterial blood HCO3. Timepoint: Before intervention and 3 months after intervention. Method of measurement: Arterial blood gas measurement will be assessed by the optical method by the Edan device in the laboratory of Luqman Hakim Hospital.

Secondary Outcome Measures

Name	Time	Method
Serum creatinine level. Timepoint: Before intervention and 3 months after intervention. Method of measurement: It will be assessed by the Pars Azmoon kit in the laboratory of Luqman Hakim Hospital.;Glomerular filtration rate. Timepoint: Before intervention and 3 months after intervention. Method of measurement: eGFR (mL/min)= [(140 - age) × Wt / (0.814 × Serum Creatinine level in µmol/L)] × (0.85 if female).