Gut Microbiome Associated Study of Shanghai Infants With Jaundice
- Conditions
- Gastrointestinal Microbiome
- Interventions
- Dietary Supplement: Probiotics
- Registration Number
- NCT03510936
- Lead Sponsor
- Shanghai 10th People's Hospital
- Brief Summary
The purpose of this study is to evaluate the effect of probiotics on the gut microbiome of infants with jaundice.
- Detailed Description
This study aims to examin the impact of probiotics administration during the process of infants jaundice treatment and recovery phase.the recovery phase.Birth,7 days,14 days and 42 days data will be collected and put into analysis to provide some suggestions on the probiotics use in the clinical for the infants with jaundice.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 30
- Newborns with jaundice treated with blue light phototherapy
- Gestational weeks <37 Birth weight <2500g or ≥4000g History of asphyxia anoxia at birth With infectious diseases treated with antibiotic With congenital metabolic diseases or hereditary diseases With gastrointestinal diseases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description probiotics concurrent with phototherapy Probiotics the patients in this arm will receive probiotics blend of Bifidobacterium longum, Lactobacillus acidophilus, Enterococcus faecalis for 2 weeks
- Primary Outcome Measures
Name Time Method change from birth,7 days,14 days on gut microbiome at 42 days by 16S rRNA 42 days change of the gut microbiome will be calculated at 42 days in comparison with birth,7 days,14 days
- Secondary Outcome Measures
Name Time Method change from birth on gut microbiome at 7 days by 16S rRNA 7 days change of the gut microbiome will be calculated at 7 days in comparison with baseline
change from birth and 7 days on gut microbiome at 14 days by 16S rRNA 14 days change of the gut microbiome will be calculated at 14 days in comparison with birth and 7 days
Trial Locations
- Locations (1)
Shanghai 10th People's Hospital
🇨🇳Shanghai, China