Effect of Probiotics on the Gut Mircobiome of Infants With Jaundice
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- change from birth,7 days,14 days on gut microbiome at 42 days by 16S rRNA
研究概览
简要总结
The purpose of this study is to evaluate the effect of probiotics on the gut microbiome of infants with jaundice.
详细描述
This study aims to examin the impact of probiotics administration during the process of infants jaundice treatment and recovery phase.the recovery phase.Birth,7 days,14 days and 42 days data will be collected and put into analysis to provide some suggestions on the probiotics use in the clinical for the infants with jaundice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 1 Hour 至 28 Days（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Newborns with jaundice treated with blue light phototherapy
排除标准
- •Gestational weeks <37 Birth weight <2500g or ≥4000g History of asphyxia anoxia at birth With infectious diseases treated with antibiotic With congenital metabolic diseases or hereditary diseases With gastrointestinal diseases
研究组 & 干预措施
blue light phototherapy
the patients in this arm will not receive probiotics.
probiotics concurrent with phototherapy
the patients in this arm will receive probiotics blend of Bifidobacterium longum, Lactobacillus acidophilus, Enterococcus faecalis for 2 weeks
干预措施: Probiotics (Dietary Supplement)
结局指标
主要结局
change from birth,7 days,14 days on gut microbiome at 42 days by 16S rRNA
时间窗: 42 days
change of the gut microbiome will be calculated at 42 days in comparison with birth,7 days,14 days
次要结局
- change from birth on gut microbiome at 7 days by 16S rRNA(7 days)
- change from birth and 7 days on gut microbiome at 14 days by 16S rRNA(14 days)
研究者
Huanlong Qin
Director
Shanghai 10th People's Hospital